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Assessing trial representativeness using serious adverse events: an observational analysis using aggregate and individual-level data from clinical trials and routine healthcare data

BACKGROUND: The applicability of randomised controlled trials of pharmacological agents to older people with frailty/multimorbidity is often uncertain, due to concerns that trials are not representative. However, assessing trial representativeness is challenging and complex. We explore an approach a...

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Detalles Bibliográficos
Autores principales:	Hanlon, Peter, Butterly, Elaine, Shah, Anoop S. V., Hannigan, Laurie J., Wild, Sarah H., Guthrie, Bruce, Mair, Frances S., Dias, Sofia, Welton, Nicky J., McAllister, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615407/ https://www.ncbi.nlm.nih.gov/pubmed/36303169 http://dx.doi.org/10.1186/s12916-022-02594-9

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