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Case-control study on CYP4B1 gene polymorphism and susceptibility to gastric cancer in the chinese Han population
BACKGROUND: In China, gastric cancer (GC) is one of the most common malignant tumors. This study aimed to explore the relationship of rs2297810, rs4646491 and rs2297809 polymorphisms of CYP4B1 with susceptibility to GC in the Chinese Han population. METHODS: A case-control study including 707 GC cas...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615408/ https://www.ncbi.nlm.nih.gov/pubmed/36307788 http://dx.doi.org/10.1186/s12920-022-01367-w |
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author | Yu, Shuyong Chen, Zhuang Cheng, Jiajia Shi, Xingang Liu, Jiaqi Zhong, Ping Song, Jian |
author_facet | Yu, Shuyong Chen, Zhuang Cheng, Jiajia Shi, Xingang Liu, Jiaqi Zhong, Ping Song, Jian |
author_sort | Yu, Shuyong |
collection | PubMed |
description | BACKGROUND: In China, gastric cancer (GC) is one of the most common malignant tumors. This study aimed to explore the relationship of rs2297810, rs4646491 and rs2297809 polymorphisms of CYP4B1 with susceptibility to GC in the Chinese Han population. METHODS: A case-control study including 707 GC cases and 707 normal controls was conducted. Three single nucleotide polymorphisms (SNPs) were genotyped by Agena MassARRAY system. Logistic regression analysis was utilized to assess the effects of SNPs on GC risk. Furthermore, multifactor dimensionality reduction (MDR) approach was used to analyze the SNP-SNP interactions. RESULTS: No significant relationships were found between rs2297810 and rs2297809 and GC risk under all genetic models. For rs4646491, people with TC genotype had a 1.40-fold higher risk of GC than those with CC genotype (OR = 1.40; 95% CI = 1.13–1.74; p = 0.002), and people with TT-TC genotype had a 1.30-fold higher risk of GC than those with CC genotype (OR = 1.30; 95% CI = 1.06–1.61; p = 0.014). Stratification results showed that GC risk in people carrying TC genotype was higher than that in people with CC genotype, males (OR = 1.36; 95% CI = 1.06–1.75; p = 0.015), non-smokers (OR = 1.52; 95% CI = 1.11–2.07; p = 0.009) and non-drinkers (OR = 1.50; 95% CI = 1.10–2.04; p = 0.010). Additionally, the study also revealed that GC risk in people carrying TT-TC genotype was higher than that in people with CC genotype, males (OR = 1.29; 95% CI = 1.01–1.64; p = 0.040), non-smokers (OR = 1.40; 95% CI = 1.04–1.89; p = 0.027) and non-drinkers (OR = 1.39; 95% CI = 1.03–1.87; p = 0.030). CONCLUSION: This study firstly found that CYP4B1-rs4646491 was significantly correlated with GC risk, and it might be a risk factor for GC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12920-022-01367-w. |
format | Online Article Text |
id | pubmed-9615408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-96154082022-10-29 Case-control study on CYP4B1 gene polymorphism and susceptibility to gastric cancer in the chinese Han population Yu, Shuyong Chen, Zhuang Cheng, Jiajia Shi, Xingang Liu, Jiaqi Zhong, Ping Song, Jian BMC Med Genomics Research BACKGROUND: In China, gastric cancer (GC) is one of the most common malignant tumors. This study aimed to explore the relationship of rs2297810, rs4646491 and rs2297809 polymorphisms of CYP4B1 with susceptibility to GC in the Chinese Han population. METHODS: A case-control study including 707 GC cases and 707 normal controls was conducted. Three single nucleotide polymorphisms (SNPs) were genotyped by Agena MassARRAY system. Logistic regression analysis was utilized to assess the effects of SNPs on GC risk. Furthermore, multifactor dimensionality reduction (MDR) approach was used to analyze the SNP-SNP interactions. RESULTS: No significant relationships were found between rs2297810 and rs2297809 and GC risk under all genetic models. For rs4646491, people with TC genotype had a 1.40-fold higher risk of GC than those with CC genotype (OR = 1.40; 95% CI = 1.13–1.74; p = 0.002), and people with TT-TC genotype had a 1.30-fold higher risk of GC than those with CC genotype (OR = 1.30; 95% CI = 1.06–1.61; p = 0.014). Stratification results showed that GC risk in people carrying TC genotype was higher than that in people with CC genotype, males (OR = 1.36; 95% CI = 1.06–1.75; p = 0.015), non-smokers (OR = 1.52; 95% CI = 1.11–2.07; p = 0.009) and non-drinkers (OR = 1.50; 95% CI = 1.10–2.04; p = 0.010). Additionally, the study also revealed that GC risk in people carrying TT-TC genotype was higher than that in people with CC genotype, males (OR = 1.29; 95% CI = 1.01–1.64; p = 0.040), non-smokers (OR = 1.40; 95% CI = 1.04–1.89; p = 0.027) and non-drinkers (OR = 1.39; 95% CI = 1.03–1.87; p = 0.030). CONCLUSION: This study firstly found that CYP4B1-rs4646491 was significantly correlated with GC risk, and it might be a risk factor for GC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12920-022-01367-w. BioMed Central 2022-10-28 /pmc/articles/PMC9615408/ /pubmed/36307788 http://dx.doi.org/10.1186/s12920-022-01367-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Yu, Shuyong Chen, Zhuang Cheng, Jiajia Shi, Xingang Liu, Jiaqi Zhong, Ping Song, Jian Case-control study on CYP4B1 gene polymorphism and susceptibility to gastric cancer in the chinese Han population |
title | Case-control study on CYP4B1 gene polymorphism and susceptibility to gastric cancer in the chinese Han population |
title_full | Case-control study on CYP4B1 gene polymorphism and susceptibility to gastric cancer in the chinese Han population |
title_fullStr | Case-control study on CYP4B1 gene polymorphism and susceptibility to gastric cancer in the chinese Han population |
title_full_unstemmed | Case-control study on CYP4B1 gene polymorphism and susceptibility to gastric cancer in the chinese Han population |
title_short | Case-control study on CYP4B1 gene polymorphism and susceptibility to gastric cancer in the chinese Han population |
title_sort | case-control study on cyp4b1 gene polymorphism and susceptibility to gastric cancer in the chinese han population |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615408/ https://www.ncbi.nlm.nih.gov/pubmed/36307788 http://dx.doi.org/10.1186/s12920-022-01367-w |
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