Nosocomial outbreak by NDM-1-producing Klebsiella pneumoniae highly resistant to cefiderocol, Florence, Italy, August 2021 to June 2022

A nosocomial outbreak by cefiderocol (FDC)-resistant NDM-1-producing Klebsiella pneumoniae (NDM-Kp) occurred in a large tertiary care hospital from August 2021–June 2022 in Florence, Italy, an area where NDM-Kp strains have become endemic. Retrospective analysis of NDM-Kp from cases observed in Janu...

Descripción completa

Detalles Bibliográficos
Autores principales: Coppi, Marco, Antonelli, Alberto, Niccolai, Claudia, Bartolini, Andrea, Bartolini, Laura, Grazzini, Maddalena, Mantengoli, Elisabetta, Farese, Alberto, Pieralli, Filippo, Mechi, Maria Teresa, Di Pilato, Vincenzo, Giani, Tommaso, Rossolini, Gian Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2022
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615416/
https://www.ncbi.nlm.nih.gov/pubmed/36305334
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.43.2200795
Descripción
Sumario:A nosocomial outbreak by cefiderocol (FDC)-resistant NDM-1-producing Klebsiella pneumoniae (NDM-Kp) occurred in a large tertiary care hospital from August 2021–June 2022 in Florence, Italy, an area where NDM-Kp strains have become endemic. Retrospective analysis of NDM-Kp from cases observed in January 2021–June 2022 revealed that 21/52 were FDC-resistant. The outbreak was mostly sustained by clonal expansion of a mutant with inactivated cirA siderophore receptor gene, which exhibited high-level resistance to FDC (MIC ≥ 32 mg/L) and spread independently of FDC exposure.

Ejemplares similares