Nosocomial outbreak by NDM-1-producing Klebsiella pneumoniae highly resistant to cefiderocol, Florence, Italy, August 2021 to June 2022

A nosocomial outbreak by cefiderocol (FDC)-resistant NDM-1-producing Klebsiella pneumoniae (NDM-Kp) occurred in a large tertiary care hospital from August 2021–June 2022 in Florence, Italy, an area where NDM-Kp strains have become endemic. Retrospective analysis of NDM-Kp from cases observed in Janu...

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Autores principales: Coppi, Marco, Antonelli, Alberto, Niccolai, Claudia, Bartolini, Andrea, Bartolini, Laura, Grazzini, Maddalena, Mantengoli, Elisabetta, Farese, Alberto, Pieralli, Filippo, Mechi, Maria Teresa, Di Pilato, Vincenzo, Giani, Tommaso, Rossolini, Gian Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2022
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615416/
https://www.ncbi.nlm.nih.gov/pubmed/36305334
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.43.2200795
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author Coppi, Marco
Antonelli, Alberto
Niccolai, Claudia
Bartolini, Andrea
Bartolini, Laura
Grazzini, Maddalena
Mantengoli, Elisabetta
Farese, Alberto
Pieralli, Filippo
Mechi, Maria Teresa
Di Pilato, Vincenzo
Giani, Tommaso
Rossolini, Gian Maria
author_facet Coppi, Marco
Antonelli, Alberto
Niccolai, Claudia
Bartolini, Andrea
Bartolini, Laura
Grazzini, Maddalena
Mantengoli, Elisabetta
Farese, Alberto
Pieralli, Filippo
Mechi, Maria Teresa
Di Pilato, Vincenzo
Giani, Tommaso
Rossolini, Gian Maria
author_sort Coppi, Marco
collection PubMed
description A nosocomial outbreak by cefiderocol (FDC)-resistant NDM-1-producing Klebsiella pneumoniae (NDM-Kp) occurred in a large tertiary care hospital from August 2021–June 2022 in Florence, Italy, an area where NDM-Kp strains have become endemic. Retrospective analysis of NDM-Kp from cases observed in January 2021–June 2022 revealed that 21/52 were FDC-resistant. The outbreak was mostly sustained by clonal expansion of a mutant with inactivated cirA siderophore receptor gene, which exhibited high-level resistance to FDC (MIC ≥ 32 mg/L) and spread independently of FDC exposure.
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spelling pubmed-96154162022-11-03 Nosocomial outbreak by NDM-1-producing Klebsiella pneumoniae highly resistant to cefiderocol, Florence, Italy, August 2021 to June 2022 Coppi, Marco Antonelli, Alberto Niccolai, Claudia Bartolini, Andrea Bartolini, Laura Grazzini, Maddalena Mantengoli, Elisabetta Farese, Alberto Pieralli, Filippo Mechi, Maria Teresa Di Pilato, Vincenzo Giani, Tommaso Rossolini, Gian Maria Euro Surveill Rapid Communication A nosocomial outbreak by cefiderocol (FDC)-resistant NDM-1-producing Klebsiella pneumoniae (NDM-Kp) occurred in a large tertiary care hospital from August 2021–June 2022 in Florence, Italy, an area where NDM-Kp strains have become endemic. Retrospective analysis of NDM-Kp from cases observed in January 2021–June 2022 revealed that 21/52 were FDC-resistant. The outbreak was mostly sustained by clonal expansion of a mutant with inactivated cirA siderophore receptor gene, which exhibited high-level resistance to FDC (MIC ≥ 32 mg/L) and spread independently of FDC exposure. European Centre for Disease Prevention and Control (ECDC) 2022-10-27 /pmc/articles/PMC9615416/ /pubmed/36305334 http://dx.doi.org/10.2807/1560-7917.ES.2022.27.43.2200795 Text en This article is copyright of the authors or their affiliated institutions, 2022. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Coppi, Marco
Antonelli, Alberto
Niccolai, Claudia
Bartolini, Andrea
Bartolini, Laura
Grazzini, Maddalena
Mantengoli, Elisabetta
Farese, Alberto
Pieralli, Filippo
Mechi, Maria Teresa
Di Pilato, Vincenzo
Giani, Tommaso
Rossolini, Gian Maria
Nosocomial outbreak by NDM-1-producing Klebsiella pneumoniae highly resistant to cefiderocol, Florence, Italy, August 2021 to June 2022
title Nosocomial outbreak by NDM-1-producing Klebsiella pneumoniae highly resistant to cefiderocol, Florence, Italy, August 2021 to June 2022
title_full Nosocomial outbreak by NDM-1-producing Klebsiella pneumoniae highly resistant to cefiderocol, Florence, Italy, August 2021 to June 2022
title_fullStr Nosocomial outbreak by NDM-1-producing Klebsiella pneumoniae highly resistant to cefiderocol, Florence, Italy, August 2021 to June 2022
title_full_unstemmed Nosocomial outbreak by NDM-1-producing Klebsiella pneumoniae highly resistant to cefiderocol, Florence, Italy, August 2021 to June 2022
title_short Nosocomial outbreak by NDM-1-producing Klebsiella pneumoniae highly resistant to cefiderocol, Florence, Italy, August 2021 to June 2022
title_sort nosocomial outbreak by ndm-1-producing klebsiella pneumoniae highly resistant to cefiderocol, florence, italy, august 2021 to june 2022
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615416/
https://www.ncbi.nlm.nih.gov/pubmed/36305334
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.43.2200795
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