Evaluation of the metabolism of PEP06, an endostatin-RGDRGD 30-amino-acid polypeptide and a promising novel drug for targeting tumor cells

PEP06 is a novel endostatin-Arg-Gly-Asp-Arg-Gly-Asp (RGDRGD) 30-amino-acid polypeptide featuring a terminally fused RGDRGD hexapeptide at the N terminus. The active endostatin fragment of PEP06 directly targets tumor cells and exerts an antitumoral effect. However, little is known about the kinetics...

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Detalles Bibliográficos
Autores principales: Niu, Liyun, Zhou, Huiyu, Lian, Yueru, Gao, Ya, Liu, Yulu, Gu, Ruolan, Wu, Zhuona, Zhu, Xiaoxia, Gan, Hui, Meng, Zhiyun, Dou, Guifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9615537/
https://www.ncbi.nlm.nih.gov/pubmed/36320606
http://dx.doi.org/10.1016/j.jpha.2022.03.002

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