Accumulation of misfolded SOD1 outlines distinct patterns of motor neuron pathology and death during disease progression in a SOD1(G93A) mouse model of amyotrophic lateral sclerosis

Early misfolded superoxide dismutase 1 (mfSOD1) accumulation, motor neuron (MN) degeneration, and microgliosis are hallmark pathological features in SOD1(G93A) amyotrophic lateral sclerosis (ALS) mice. Because of the different vulnerabilities of distinct MN subtypes, degenerating and surviving MNs c...

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Detalles Bibliográficos
Autores principales: Salvany, Sara, Casanovas, Anna, Piedrafita, Lídia, Gras, Sílvia, Calderó, Jordi, Esquerda, Josep E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616096/
https://www.ncbi.nlm.nih.gov/pubmed/35584812
http://dx.doi.org/10.1111/bpa.13078

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