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Error-Related Brain Activity in Patients With Obsessive-Compulsive Disorder and Unaffected First-Degree Relatives: Evidence for Protective Patterns

BACKGROUND: Indicators of increased error monitoring are associated with obsessive-compulsive disorder (OCD), as shown in electroencephalography and functional magnetic resonance imaging studies. As most studies used strictly controlled samples (excluding comorbidity and medication), it remains open...

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Autores principales: Grützmann, Rosa, Kaufmann, Christian, Wudarczyk, Olga A., Balzus, Luisa, Klawohn, Julia, Riesel, Anja, Bey, Katharina, Wagner, Michael, Heinzel, Stephan, Kathmann, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616249/
https://www.ncbi.nlm.nih.gov/pubmed/36324601
http://dx.doi.org/10.1016/j.bpsgos.2021.07.001
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author Grützmann, Rosa
Kaufmann, Christian
Wudarczyk, Olga A.
Balzus, Luisa
Klawohn, Julia
Riesel, Anja
Bey, Katharina
Wagner, Michael
Heinzel, Stephan
Kathmann, Norbert
author_facet Grützmann, Rosa
Kaufmann, Christian
Wudarczyk, Olga A.
Balzus, Luisa
Klawohn, Julia
Riesel, Anja
Bey, Katharina
Wagner, Michael
Heinzel, Stephan
Kathmann, Norbert
author_sort Grützmann, Rosa
collection PubMed
description BACKGROUND: Indicators of increased error monitoring are associated with obsessive-compulsive disorder (OCD), as shown in electroencephalography and functional magnetic resonance imaging studies. As most studies used strictly controlled samples (excluding comorbidity and medication), it remains open whether these findings extend to naturalistic settings. Thus, we assessed error-related brain activity in a large, naturalistic OCD sample. We also explored which activity patterns might qualify as vulnerability endophenotypes or protective factors for the disorder. To this aim, a sample of unaffected first-degree relatives of patients with OCD was also included. METHODS: Participants (84 patients with OCD, 99 healthy control participants, and 37 unaffected first-degree relatives of patients with OCD) completed a flanker task while blood oxygen level–dependent responses were measured with functional magnetic resonance imaging. Aberrant error-related brain activity in patients and relatives was identified. RESULTS: Patients with OCD showed increased error-related activity in the supplementary motor area and within the default mode network, specifically in the precuneus and postcentral gyrus. Unaffected first-degree relatives showed increased error-related activity in the bilateral inferior frontal gyrus. CONCLUSIONS: Increased supplementary motor area and default mode network activity in patients with OCD replicates previous studies and might indicate excessive error signals and increased self-referential error processing. Increased activity of the inferior frontal gyrus in relatives may reflect increased inhibition. Impaired response inhibition in OCD has been demonstrated in several studies and might contribute to impairments in suppressing compulsive actions. Thus, increased inferior frontal gyrus activity in the unaffected relatives of patients with OCD may have contributed to protection from symptom development.
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spelling pubmed-96162492022-11-01 Error-Related Brain Activity in Patients With Obsessive-Compulsive Disorder and Unaffected First-Degree Relatives: Evidence for Protective Patterns Grützmann, Rosa Kaufmann, Christian Wudarczyk, Olga A. Balzus, Luisa Klawohn, Julia Riesel, Anja Bey, Katharina Wagner, Michael Heinzel, Stephan Kathmann, Norbert Biol Psychiatry Glob Open Sci Archival Report BACKGROUND: Indicators of increased error monitoring are associated with obsessive-compulsive disorder (OCD), as shown in electroencephalography and functional magnetic resonance imaging studies. As most studies used strictly controlled samples (excluding comorbidity and medication), it remains open whether these findings extend to naturalistic settings. Thus, we assessed error-related brain activity in a large, naturalistic OCD sample. We also explored which activity patterns might qualify as vulnerability endophenotypes or protective factors for the disorder. To this aim, a sample of unaffected first-degree relatives of patients with OCD was also included. METHODS: Participants (84 patients with OCD, 99 healthy control participants, and 37 unaffected first-degree relatives of patients with OCD) completed a flanker task while blood oxygen level–dependent responses were measured with functional magnetic resonance imaging. Aberrant error-related brain activity in patients and relatives was identified. RESULTS: Patients with OCD showed increased error-related activity in the supplementary motor area and within the default mode network, specifically in the precuneus and postcentral gyrus. Unaffected first-degree relatives showed increased error-related activity in the bilateral inferior frontal gyrus. CONCLUSIONS: Increased supplementary motor area and default mode network activity in patients with OCD replicates previous studies and might indicate excessive error signals and increased self-referential error processing. Increased activity of the inferior frontal gyrus in relatives may reflect increased inhibition. Impaired response inhibition in OCD has been demonstrated in several studies and might contribute to impairments in suppressing compulsive actions. Thus, increased inferior frontal gyrus activity in the unaffected relatives of patients with OCD may have contributed to protection from symptom development. Elsevier 2021-07-15 /pmc/articles/PMC9616249/ /pubmed/36324601 http://dx.doi.org/10.1016/j.bpsgos.2021.07.001 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Archival Report
Grützmann, Rosa
Kaufmann, Christian
Wudarczyk, Olga A.
Balzus, Luisa
Klawohn, Julia
Riesel, Anja
Bey, Katharina
Wagner, Michael
Heinzel, Stephan
Kathmann, Norbert
Error-Related Brain Activity in Patients With Obsessive-Compulsive Disorder and Unaffected First-Degree Relatives: Evidence for Protective Patterns
title Error-Related Brain Activity in Patients With Obsessive-Compulsive Disorder and Unaffected First-Degree Relatives: Evidence for Protective Patterns
title_full Error-Related Brain Activity in Patients With Obsessive-Compulsive Disorder and Unaffected First-Degree Relatives: Evidence for Protective Patterns
title_fullStr Error-Related Brain Activity in Patients With Obsessive-Compulsive Disorder and Unaffected First-Degree Relatives: Evidence for Protective Patterns
title_full_unstemmed Error-Related Brain Activity in Patients With Obsessive-Compulsive Disorder and Unaffected First-Degree Relatives: Evidence for Protective Patterns
title_short Error-Related Brain Activity in Patients With Obsessive-Compulsive Disorder and Unaffected First-Degree Relatives: Evidence for Protective Patterns
title_sort error-related brain activity in patients with obsessive-compulsive disorder and unaffected first-degree relatives: evidence for protective patterns
topic Archival Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616249/
https://www.ncbi.nlm.nih.gov/pubmed/36324601
http://dx.doi.org/10.1016/j.bpsgos.2021.07.001
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