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Proof-of-Mechanism Study of the Phosphodiesterase 10 Inhibitor RG7203 in Patients With Schizophrenia and Negative Symptoms

BACKGROUND: Reduced activation of dopamine D(1) receptor signaling may be implicated in reward functioning as a potential driver of negative symptoms in schizophrenia. Phosphodiesterase 10A (PDE10A), an enzyme that is highly expressed in the striatum, modulates both dopamine D(2)- and D(1)-dependent...

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Detalles Bibliográficos
Autores principales:	Umbricht, Daniel, Abt, Markus, Tamburri, Paul, Chatham, Christopher, Holiga, Štefan, Frank, Michael J., Collins, Anne G.E., Walling, David P., Mofsen, Rick, Gruener, Daniel, Gertsik, Lev, Sevigny, Jeff, Keswani, Sanjay, Dukart, Juergen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Archival Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616307/ https://www.ncbi.nlm.nih.gov/pubmed/36324430 http://dx.doi.org/10.1016/j.bpsgos.2021.03.001

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