Cognition, mood and behavior in CADASIL

CADASIL is the most common familial cerebral small vessel disease (cSVD). Stereotyped mutations of the NOTCH3 gene are responsible for this archetypal ischemic cSVD that can lead, at the very end stage, to severe dementia. Variable cognitive alterations, mood, or behavior disturbances are frequently...

Descripción completa

Detalles Bibliográficos
Autores principales: Chabriat, Hugues, Lesnik Oberstein, Saskia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616390/
https://www.ncbi.nlm.nih.gov/pubmed/36324403
http://dx.doi.org/10.1016/j.cccb.2022.100043
_version_ 1784820633370099712
author Chabriat, Hugues
Lesnik Oberstein, Saskia
author_facet Chabriat, Hugues
Lesnik Oberstein, Saskia
author_sort Chabriat, Hugues
collection PubMed
description CADASIL is the most common familial cerebral small vessel disease (cSVD). Stereotyped mutations of the NOTCH3 gene are responsible for this archetypal ischemic cSVD that can lead, at the very end stage, to severe dementia. Variable cognitive alterations, mood, or behavior disturbances are frequently observed during the course of the disease. In this review, these clinical manifestations, their occurrence, severity and duration are analyzed in relation to the disease progression. Also, the potential relationships with cerebral lesions and treatment options are discussed.
format Online
Article
Text
id pubmed-9616390
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-96163902022-11-01 Cognition, mood and behavior in CADASIL Chabriat, Hugues Lesnik Oberstein, Saskia Cereb Circ Cogn Behav Article CADASIL is the most common familial cerebral small vessel disease (cSVD). Stereotyped mutations of the NOTCH3 gene are responsible for this archetypal ischemic cSVD that can lead, at the very end stage, to severe dementia. Variable cognitive alterations, mood, or behavior disturbances are frequently observed during the course of the disease. In this review, these clinical manifestations, their occurrence, severity and duration are analyzed in relation to the disease progression. Also, the potential relationships with cerebral lesions and treatment options are discussed. Elsevier 2022-02-09 /pmc/articles/PMC9616390/ /pubmed/36324403 http://dx.doi.org/10.1016/j.cccb.2022.100043 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Chabriat, Hugues
Lesnik Oberstein, Saskia
Cognition, mood and behavior in CADASIL
title Cognition, mood and behavior in CADASIL
title_full Cognition, mood and behavior in CADASIL
title_fullStr Cognition, mood and behavior in CADASIL
title_full_unstemmed Cognition, mood and behavior in CADASIL
title_short Cognition, mood and behavior in CADASIL
title_sort cognition, mood and behavior in cadasil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616390/
https://www.ncbi.nlm.nih.gov/pubmed/36324403
http://dx.doi.org/10.1016/j.cccb.2022.100043
work_keys_str_mv AT chabriathugues cognitionmoodandbehaviorincadasil
AT lesnikobersteinsaskia cognitionmoodandbehaviorincadasil

Ejemplares similares