Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase

Neuraminidase (NA) of human influenza H3N2 virus has evolved rapidly and been accumulating mutations for more than half-century. However, biophysical constraints that govern the evolutionary trajectories of NA remain largely elusive. Here, we show that among 70 natural mutations that are present in...

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Detalles Bibliográficos
Autores principales: Lei, Ruipeng, Tan, Timothy J. C., Hernandez Garcia, Andrea, Wang, Yiquan, Diefenbacher, Meghan, Teo, Chuyun, Gopan, Gopika, Tavakoli Dargani, Zahra, Teo, Qi Wen, Graham, Claire S., Brooke, Christopher B., Nair, Satish K., Wu, Nicholas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616408/
https://www.ncbi.nlm.nih.gov/pubmed/36307418
http://dx.doi.org/10.1038/s41467-022-34060-8

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