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Increased mtDNA mutation frequency in oocytes causes epigenetic alterations and embryonic defects

Mitochondria are essential for female reproductive processes, yet the function of mitochondrial DNA (mtDNA) mutation in oocytes remains elusive. By employing an mtDNA mutator (Polg(m)) mouse model, we found the fetal growth retardation and placental dysfunction in post-implantation embryos derived f...

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Detalles Bibliográficos
Autores principales:	Han, Longsen, Chen, Yujia, Li, Ling, Ren, Chao, Wang, Haichao, Wu, Xinghan, Ge, Juan, Shu, Wenjie, Chen, Minjian, Wang, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616472/ https://www.ncbi.nlm.nih.gov/pubmed/36325113 http://dx.doi.org/10.1093/nsr/nwac136

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