Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells

Quiescent leukemic cells survive chemotherapy, with translation changes. Our data reveal that FXR1, a protein amplified in several aggressive cancers, is elevated in quiescent and chemo-treated leukemic cells and promotes chemosurvival. This suggests undiscovered roles for this RNA- and ribosome-ass...

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Detalles Bibliográficos
Autores principales: Datta, Chandreyee, Truesdell, Samuel S., Wu, Keith Q., Bukhari, Syed I. A., Ngue, Harrison, Buchanan, Brienna, Le Tonqueze, Olivier, Lee, Sooncheol, Kollu, Swapna, Granovetter, Madeleine A., Boukhali, Myriam, Kreuzer, Johannes, Batool, Maheen S., Balaj, Leonora, Haas, Wilhelm, Vasudevan, Shobha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616492/
https://www.ncbi.nlm.nih.gov/pubmed/36306353
http://dx.doi.org/10.1126/sciadv.abo1304

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