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Clinically relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance

Chemotherapy resistance and relapses are common in high-risk neuroblastoma (NB). Here, we developed a clinically relevant in vivo treatment protocol mimicking the first-line five-chemotherapy treatment regimen of high-risk NB and applied this protocol to mice with MYCN-amplified NB patient-derived x...

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Detalles Bibliográficos
Autores principales:	Mañas, Adriana, Aaltonen, Kristina, Andersson, Natalie, Hansson, Karin, Adamska, Aleksandra, Seger, Alexandra, Yasui, Hiroaki, van den Bos, Hilda, Radke, Katarzyna, Esfandyari, Javanshir, Bhave, Madhura Satish, Karlsson, Jenny, Spierings, Diana, Foijer, Floris, Gisselsson, David, Bexell, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616506/ https://www.ncbi.nlm.nih.gov/pubmed/36306349 http://dx.doi.org/10.1126/sciadv.abq4617

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