Impact of mucositis on oral bioavailability and systemic exposure of ciprofloxacin Gram-negative infection prophylaxis in patients with haematological malignancies

BACKGROUND: Patients with haematological malignancies frequently endure neutropenia and gastrointestinal (GI)-mucositis after high-dose chemotherapy. In these patients, ciprofloxacin is used for Gram-negative infection prophylaxis. OBJECTIVES: We investigate ciprofloxacin pharmacokinetics after oral...

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Detalles Bibliográficos
Autores principales: van Rhee, K P, de Vroom, S L, van Hest, R M, van der Linden, P D, Tonino, S H, Molendijk, E, Mathôt, R A A, Blijlevens, N M A, Knibbe, C A J, Bruggemann, R J M, Geerlings, S E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616544/
https://www.ncbi.nlm.nih.gov/pubmed/35996887
http://dx.doi.org/10.1093/jac/dkac283

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