Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington’s disease reveals early gray and white matter alterations

Pathogenesis of the inherited neurodegenerative disorder Huntington’s disease (HD) is progressive with a long presymptomatic phase in which subtle changes occur up to 15 years before the onset of symptoms. Thus, there is a need for early, functional biomarker to better understand disease progression...

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Detalles Bibliográficos
Autores principales: Pérot, Jean-Baptiste, Célestine, Marina, Palombo, Marco, Dhenain, Marc, Humbert, Sandrine, Brouillet, Emmanuel, Flament, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616570/
https://www.ncbi.nlm.nih.gov/pubmed/35147158
http://dx.doi.org/10.1093/hmg/ddac036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616570/
https://www.ncbi.nlm.nih.gov/pubmed/35147158
http://dx.doi.org/10.1093/hmg/ddac036

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