Mitochondrial DNA variants segregate during human preimplantation development into genetically different cell lineages that are maintained postnatally

Humans present remarkable diversity in their mitochondrial DNA (mtDNA) in terms of variants across individuals as well as across tissues and even cells within one person. We have investigated the timing of the first appearance of this variant-driven mosaicism. For this, we deep-sequenced the mtDNA o...

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Detalles Bibliográficos
Autores principales: Mertens, Joke, Regin, Marius, De Munck, Neelke, Couvreu de Deckersberg, Edouard, Belva, Florence, Sermon, Karen, Tournaye, Herman, Blockeel, Christophe, Van de Velde, Hilde, Spits, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616571/
https://www.ncbi.nlm.nih.gov/pubmed/35285472
http://dx.doi.org/10.1093/hmg/ddac059

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