Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation

A growing body of evidence suggests that nuclear alpha-synuclein (αSyn) plays a role in the pathogenesis of Parkinson’s disease (PD). However, this question has been difficult to address as controlling the localization of αSyn in experimental systems often requires protein overexpression, which affe...

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Detalles Bibliográficos
Autores principales: Geertsma, Haley M, Suk, Terry R, Ricke, Konrad M, Horsthuis, Kyra, Parmasad, Jean-Louis A, Fisk, Zoe A, Callaghan, Steve M, Rousseaux, Maxime W C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616578/
https://www.ncbi.nlm.nih.gov/pubmed/35179202
http://dx.doi.org/10.1093/hmg/ddac035

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