CVID-Associated B Cell Activating Factor Receptor Variants Change Receptor Oligomerization, Ligand Binding, and Signaling Responses

PURPOSE: Binding of the B cell activating factor (BAFF) to its receptor (BAFFR) activates in mature B cells many essential pro-survival functions. Null mutations in the BAFFR gene result in complete BAFFR deficiency and cause a block in B cell development at the transition from immature to mature B...

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Detalles Bibliográficos
Autores principales: Block, Violeta, Sevdali, Eirini, Recher, Mike, Abolhassani, Hassan, Hammarstrom, Lennart, Smulski, Cristian R., Baronio, Manuela, Plebani, Alessandro, Proietti, Michele, Speletas, Matthaios, Warnatz, Klaus, Voll, Reinhard E., Lougaris, Vassilios, Schneider, Pascal, Eibel, Hermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616699/
https://www.ncbi.nlm.nih.gov/pubmed/36308663
http://dx.doi.org/10.1007/s10875-022-01378-3

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