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Analyte-mediated formation and growth of nanoparticles for the development of chemical sensors and biosensors
The cornerstone of nanomaterial-based sensing systems is the synthesis of nanoparticles with appropriate surface functionalization that ensures their stability and determines their reactivity with organic or inorganic analytes. To accomplish these requirements, various compounds are used as additive...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616756/ https://www.ncbi.nlm.nih.gov/pubmed/36307660 http://dx.doi.org/10.1007/s00604-022-05536-7 |
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author | Tsogas, George Z. Vlessidis, Athanasios G. Giokas, Dimosthenis L. |
author_facet | Tsogas, George Z. Vlessidis, Athanasios G. Giokas, Dimosthenis L. |
author_sort | Tsogas, George Z. |
collection | PubMed |
description | The cornerstone of nanomaterial-based sensing systems is the synthesis of nanoparticles with appropriate surface functionalization that ensures their stability and determines their reactivity with organic or inorganic analytes. To accomplish these requirements, various compounds are used as additives or growth factors to regulate the properties of the synthesized nanoparticles and their reactivity with the target analytes. A different rationale is to use the target analytes as additives or growth agents to control the formation and properties of nanoparticles. The main difference is that the analyte recognition event occurs before or during the formation of nanoparticles and it is based on the reactivity of the analytes with the precursor materials of the nanoparticles (e.g., metal ions, reducing agents, and coatings). The transition from the ionic (or molecular) state of the precursor materials to ordered nanostructured assemblies is used for sensing and signal transduction for the qualitative detection and the quantitative determination of the target analytes, respectively. This review focuses on assays that are based on analyte-mediated regulation of nanoparticles’ formation and differentiate them from standard nanoparticle-based assays which rely on pre-synthesized nanoparticles. Firstly, the principles of analyte-mediated nanomaterial sensors are described and then they are discussed with emphasis on the sensing strategies, the signal transduction mechanisms, and their applications. Finally, the main advantages, as well as the limitations of this approach, are discussed and compared with assays that rely on pre-synthesized nanoparticles in order to highlight the major advances accomplished with this type of nano-sensors and elucidate challenges and opportunities for further evolving new nano-sensing strategies. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-9616756 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-96167562022-10-30 Analyte-mediated formation and growth of nanoparticles for the development of chemical sensors and biosensors Tsogas, George Z. Vlessidis, Athanasios G. Giokas, Dimosthenis L. Mikrochim Acta Review Article The cornerstone of nanomaterial-based sensing systems is the synthesis of nanoparticles with appropriate surface functionalization that ensures their stability and determines their reactivity with organic or inorganic analytes. To accomplish these requirements, various compounds are used as additives or growth factors to regulate the properties of the synthesized nanoparticles and their reactivity with the target analytes. A different rationale is to use the target analytes as additives or growth agents to control the formation and properties of nanoparticles. The main difference is that the analyte recognition event occurs before or during the formation of nanoparticles and it is based on the reactivity of the analytes with the precursor materials of the nanoparticles (e.g., metal ions, reducing agents, and coatings). The transition from the ionic (or molecular) state of the precursor materials to ordered nanostructured assemblies is used for sensing and signal transduction for the qualitative detection and the quantitative determination of the target analytes, respectively. This review focuses on assays that are based on analyte-mediated regulation of nanoparticles’ formation and differentiate them from standard nanoparticle-based assays which rely on pre-synthesized nanoparticles. Firstly, the principles of analyte-mediated nanomaterial sensors are described and then they are discussed with emphasis on the sensing strategies, the signal transduction mechanisms, and their applications. Finally, the main advantages, as well as the limitations of this approach, are discussed and compared with assays that rely on pre-synthesized nanoparticles in order to highlight the major advances accomplished with this type of nano-sensors and elucidate challenges and opportunities for further evolving new nano-sensing strategies. GRAPHICAL ABSTRACT: [Image: see text] Springer Vienna 2022-10-28 2022 /pmc/articles/PMC9616756/ /pubmed/36307660 http://dx.doi.org/10.1007/s00604-022-05536-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Tsogas, George Z. Vlessidis, Athanasios G. Giokas, Dimosthenis L. Analyte-mediated formation and growth of nanoparticles for the development of chemical sensors and biosensors |
title | Analyte-mediated formation and growth of nanoparticles for the development of chemical sensors and biosensors |
title_full | Analyte-mediated formation and growth of nanoparticles for the development of chemical sensors and biosensors |
title_fullStr | Analyte-mediated formation and growth of nanoparticles for the development of chemical sensors and biosensors |
title_full_unstemmed | Analyte-mediated formation and growth of nanoparticles for the development of chemical sensors and biosensors |
title_short | Analyte-mediated formation and growth of nanoparticles for the development of chemical sensors and biosensors |
title_sort | analyte-mediated formation and growth of nanoparticles for the development of chemical sensors and biosensors |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616756/ https://www.ncbi.nlm.nih.gov/pubmed/36307660 http://dx.doi.org/10.1007/s00604-022-05536-7 |
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