Image quality evaluation of real low-dose breast PET

PURPOSE: To evaluate the clinical feasibility of high-resolution dedicated breast positron emission tomography (dbPET) with real low-dose (18)F-2-fluorodeoxy-d-glucose ((18)F-FDG) by comparing images acquired with full-dose FDG. MATERIALS AND METHODS: Nine women with no history of breast cancer and previously scanned by dbPET injected with a clinical (18)F-FDG dose (3 MBq/kg) were enrolled. They were injected with 50% of the clinical (18)F-FDG dose and scanned with dbPET for 10 min for each breast 60 and 90 min after injection. To investigate the effect of the scan start time and acquisition time on image quality, list-mode data were divided into 1, 3, 5, and 7 min (and 10 min with 50% FDG injected) from the start of acquisition and reconstructed. The reconstructed images were visually and quantitatively compared for contrast between mammary gland and fat (contrast) and for coefficient of variation (CV) in the mammary gland. RESULTS: In visual evaluation, the contrast between the mammary gland and fat acquired at a 50% dose for 7 min was comparable and even better in smoothness than that in the images acquired at a 100% dose. No visual difference between the images with a 50% dose was found with scan start times 60 and 90 min after injection. Quantitative evaluation showed a slightly lower contrast in the image at 60 min after 50% dosing, with no difference between acquisition times. There was no difference in CV between conditions; however, smoothness decreased with shorter acquisition time in all conditions. CONCLUSIONS: The quality of dbPET images with a 50% FDG dose was high enough for clinical application. Although the optimal scan start time for improved lesion-to-background mammary gland contrast remained unknown in this study, it will be clarified in future studies of breast cancer patients.