Heterochromatic repeat clustering imposes a physical barrier on homologous recombination to prevent chromosomal translocations

Mouse pericentromeric DNA is composed of tandem major satellite repeats, which are heterochromatinized and cluster together to form chromocenters. These clusters are refractory to DNA repair through homologous recombination (HR). The mechanisms by which pericentromeric heterochromatin imposes a barr...

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Detalles Bibliográficos
Autores principales: Mitrentsi, Ioanna, Lou, Jieqiong, Kerjouan, Adèle, Verigos, John, Reina-San-Martin, Bernardo, Hinde, Elizabeth, Soutoglou, Evi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616805/
https://www.ncbi.nlm.nih.gov/pubmed/35447083
http://dx.doi.org/10.1016/j.molcel.2022.03.033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616805/
https://www.ncbi.nlm.nih.gov/pubmed/35447083
http://dx.doi.org/10.1016/j.molcel.2022.03.033

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