H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

The 53BP1-RIF1-shieldin pathway maintains genome stability by suppressing nucleolytic degradation of DNA ends at double-strand breaks (DSBs). Although RIF1 interacts with damaged chromatin via phospho-53BP1 and facilitates recruitment of the shieldin complex to DSBs, it is unclear whether other regu...

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Detalles Bibliográficos
Autores principales: Bayley, Rachel, Borel, Valerie, Moss, Rhiannon J., Sweatman, Ellie, Ruis, Philip, Ormrod, Alice, Goula, Amalia, Mottram, Rachel M.A., Stanage, Tyler, Hewitt, Graeme, Saponaro, Marco, Stewart, Grant S., Boulton, Simon J., Higgs, Martin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616806/
https://www.ncbi.nlm.nih.gov/pubmed/35439434
http://dx.doi.org/10.1016/j.molcel.2022.03.030

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