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Prevalence and clinical association of sarcopenia among Thai patients with systemic sclerosis
Patients with systemic sclerosis (SSc) have some potential factors associated with an increased risk of sarcopenia. There has been currently no study to examine such associations in SSc patients. We aimed to determine the prevalence of sarcopenia among SSc patients and examine its association with c...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616808/ https://www.ncbi.nlm.nih.gov/pubmed/36307496 http://dx.doi.org/10.1038/s41598-022-21914-w |
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author | Sangaroon, Arthitaya Foocharoen, Chingching Theerakulpisut, Daris Srichompoo, Kannikar Mahakkanukrauh, Ajanee Suwannaroj, Siraphop Seerasaporn, Patpiya Pongchaiyakul, Chatlert |
author_facet | Sangaroon, Arthitaya Foocharoen, Chingching Theerakulpisut, Daris Srichompoo, Kannikar Mahakkanukrauh, Ajanee Suwannaroj, Siraphop Seerasaporn, Patpiya Pongchaiyakul, Chatlert |
author_sort | Sangaroon, Arthitaya |
collection | PubMed |
description | Patients with systemic sclerosis (SSc) have some potential factors associated with an increased risk of sarcopenia. There has been currently no study to examine such associations in SSc patients. We aimed to determine the prevalence of sarcopenia among SSc patients and examine its association with clinical manifestations and laboratory tests. A cross-sectional study was conducted in 180 adult SSc patients at the Scleroderma Clinic, Khon Kaen University, Thailand, between July 2019 and April 2020. Clinical data, laboratory tests for inflammatory markers, serology, hormone, body composition by dual-energy X-ray absorptiometry, handgrip strength, functional lower extremity strength, and usual gait speed were collected and measured. Sarcopenia was defined according to the criteria of the Asian Working Group for Sarcopenia. One hundred and eighty patients were recruited. Ninety-four cases (52.2%) were the diffuse cutaneous SSc subset. The respective mean age and duration of disease was 58.8 ± 9.4 and 6.2 ± 5.3 years. Sarcopenia was revealed in 41 SSc patients for a prevalence of 22.8% (95% CI 12.1–34.8), while the prevalence was higher in patients with the diffuse cutaneous SSc (dcSSc) compared to the limited cutaneous SSc. BMI at the onset of SSc and C-reactive protein > 5 mg/dL were significantly associated with sarcopenia with a respective OR of 0.60 (95% CI 0.48–0.75) and 3.18 (1.06–9.54). Sarcopenia is common in patients with SSc, but the prevalence is more pronounced in the dcSSc. Inflammatory markers, particularly the CRP level, are strongly associated. BMI at the onset had a negative association with sarcopenia among SSc patients. |
format | Online Article Text |
id | pubmed-9616808 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-96168082022-10-30 Prevalence and clinical association of sarcopenia among Thai patients with systemic sclerosis Sangaroon, Arthitaya Foocharoen, Chingching Theerakulpisut, Daris Srichompoo, Kannikar Mahakkanukrauh, Ajanee Suwannaroj, Siraphop Seerasaporn, Patpiya Pongchaiyakul, Chatlert Sci Rep Article Patients with systemic sclerosis (SSc) have some potential factors associated with an increased risk of sarcopenia. There has been currently no study to examine such associations in SSc patients. We aimed to determine the prevalence of sarcopenia among SSc patients and examine its association with clinical manifestations and laboratory tests. A cross-sectional study was conducted in 180 adult SSc patients at the Scleroderma Clinic, Khon Kaen University, Thailand, between July 2019 and April 2020. Clinical data, laboratory tests for inflammatory markers, serology, hormone, body composition by dual-energy X-ray absorptiometry, handgrip strength, functional lower extremity strength, and usual gait speed were collected and measured. Sarcopenia was defined according to the criteria of the Asian Working Group for Sarcopenia. One hundred and eighty patients were recruited. Ninety-four cases (52.2%) were the diffuse cutaneous SSc subset. The respective mean age and duration of disease was 58.8 ± 9.4 and 6.2 ± 5.3 years. Sarcopenia was revealed in 41 SSc patients for a prevalence of 22.8% (95% CI 12.1–34.8), while the prevalence was higher in patients with the diffuse cutaneous SSc (dcSSc) compared to the limited cutaneous SSc. BMI at the onset of SSc and C-reactive protein > 5 mg/dL were significantly associated with sarcopenia with a respective OR of 0.60 (95% CI 0.48–0.75) and 3.18 (1.06–9.54). Sarcopenia is common in patients with SSc, but the prevalence is more pronounced in the dcSSc. Inflammatory markers, particularly the CRP level, are strongly associated. BMI at the onset had a negative association with sarcopenia among SSc patients. Nature Publishing Group UK 2022-10-28 /pmc/articles/PMC9616808/ /pubmed/36307496 http://dx.doi.org/10.1038/s41598-022-21914-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Sangaroon, Arthitaya Foocharoen, Chingching Theerakulpisut, Daris Srichompoo, Kannikar Mahakkanukrauh, Ajanee Suwannaroj, Siraphop Seerasaporn, Patpiya Pongchaiyakul, Chatlert Prevalence and clinical association of sarcopenia among Thai patients with systemic sclerosis |
title | Prevalence and clinical association of sarcopenia among Thai patients with systemic sclerosis |
title_full | Prevalence and clinical association of sarcopenia among Thai patients with systemic sclerosis |
title_fullStr | Prevalence and clinical association of sarcopenia among Thai patients with systemic sclerosis |
title_full_unstemmed | Prevalence and clinical association of sarcopenia among Thai patients with systemic sclerosis |
title_short | Prevalence and clinical association of sarcopenia among Thai patients with systemic sclerosis |
title_sort | prevalence and clinical association of sarcopenia among thai patients with systemic sclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616808/ https://www.ncbi.nlm.nih.gov/pubmed/36307496 http://dx.doi.org/10.1038/s41598-022-21914-w |
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