Wildtype heterogeneity contributes to clonal variability in genome edited cells

Genome editing tools such as CRISPR/Cas9 enable the rapid and precise manipulation of genomes. CRISPR-based genome editing has greatly simplified the study of gene function in cell lines, but its widespread use has also highlighted challenges of reproducibility. Phenotypic variability among differen...

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Detalles Bibliográficos
Autores principales: Westermann, Lukas, Li, Yong, Göcmen, Burulca, Niedermoser, Matthias, Rhein, Kilian, Jahn, Johannes, Cascante, Isabel, Schöler, Felix, Moser, Niklas, Neubauer, Björn, Hofherr, Alexis, Behrens, Yvonne Lisa, Göhring, Gudrun, Köttgen, Anna, Köttgen, Michael, Busch, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616811/
https://www.ncbi.nlm.nih.gov/pubmed/36307508
http://dx.doi.org/10.1038/s41598-022-22885-8

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