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The N(6)-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity

During erythroid differentiation, the maintenance of genome integrity is key for the success of multiple rounds of cell division. However, molecular mechanisms coordinating the expression of DNA repair machinery in erythroid progenitors are poorly understood. Here, we discover that an RNA N(6)-methy...

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Detalles Bibliográficos
Autores principales: Yoshinaga, Masanori, Han, Kyuho, Morgens, David W., Horii, Takuro, Kobayashi, Ryosuke, Tsuruyama, Tatsuaki, Hia, Fabian, Yasukura, Shota, Kajiya, Asako, Cai, Ting, Cruz, Pedro H. C., Vandenbon, Alexis, Suzuki, Yutaka, Kawahara, Yukio, Hatada, Izuho, Bassik, Michael C., Takeuchi, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616860/
https://www.ncbi.nlm.nih.gov/pubmed/36307435
http://dx.doi.org/10.1038/s41467-022-34078-y