Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA

N6-methyladenosine (m(6)A) is abundant in the mammalian brain and is considered to have a wide range of effects on learning and memory. Here, we found that the upregulated methyltransferase-like protein 16 (METTL16) in the hippocampal tissues of Morris water maze (MWM)-trained mice contributed to im...

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Detalles Bibliográficos
Autores principales: Zhang, Runjiao, Zhang, Yizhou, Guo, Fangzhen, Huang, Guannan, Zhao, Yan, Chen, Bingyu, Wang, Chang, Cui, Chengran, Shi, Yichun, Li, Sha, Cui, Huixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616879/
https://www.ncbi.nlm.nih.gov/pubmed/36307396
http://dx.doi.org/10.1038/s41420-022-01220-0
Descripción
Sumario:N6-methyladenosine (m(6)A) is abundant in the mammalian brain and is considered to have a wide range of effects on learning and memory. Here, we found that the upregulated methyltransferase-like protein 16 (METTL16) in the hippocampal tissues of Morris water maze (MWM)-trained mice contributed to improved memory formation and hippocampal synaptic plasticity. Mechanismly, METTL16 promoted the expression of methionine adenosyltransferase 2A (MAT2A) by the m(6)A methylation of the MAT2A mRNA-3′UTR-end to increase its stability, and this involved in improving hippocampal global m(6)A levels, plasticity of dendritic spine, learning and memory. This study provides a new perspective to explore the regulatory mechanisms of m(6)A for learning and memory. [Image: see text]

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