Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA

N6-methyladenosine (m(6)A) is abundant in the mammalian brain and is considered to have a wide range of effects on learning and memory. Here, we found that the upregulated methyltransferase-like protein 16 (METTL16) in the hippocampal tissues of Morris water maze (MWM)-trained mice contributed to im...

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Autores principales: Zhang, Runjiao, Zhang, Yizhou, Guo, Fangzhen, Huang, Guannan, Zhao, Yan, Chen, Bingyu, Wang, Chang, Cui, Chengran, Shi, Yichun, Li, Sha, Cui, Huixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616879/
https://www.ncbi.nlm.nih.gov/pubmed/36307396
http://dx.doi.org/10.1038/s41420-022-01220-0
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author Zhang, Runjiao
Zhang, Yizhou
Guo, Fangzhen
Huang, Guannan
Zhao, Yan
Chen, Bingyu
Wang, Chang
Cui, Chengran
Shi, Yichun
Li, Sha
Cui, Huixian
author_facet Zhang, Runjiao
Zhang, Yizhou
Guo, Fangzhen
Huang, Guannan
Zhao, Yan
Chen, Bingyu
Wang, Chang
Cui, Chengran
Shi, Yichun
Li, Sha
Cui, Huixian
author_sort Zhang, Runjiao
collection PubMed
description N6-methyladenosine (m(6)A) is abundant in the mammalian brain and is considered to have a wide range of effects on learning and memory. Here, we found that the upregulated methyltransferase-like protein 16 (METTL16) in the hippocampal tissues of Morris water maze (MWM)-trained mice contributed to improved memory formation and hippocampal synaptic plasticity. Mechanismly, METTL16 promoted the expression of methionine adenosyltransferase 2A (MAT2A) by the m(6)A methylation of the MAT2A mRNA-3′UTR-end to increase its stability, and this involved in improving hippocampal global m(6)A levels, plasticity of dendritic spine, learning and memory. This study provides a new perspective to explore the regulatory mechanisms of m(6)A for learning and memory. [Image: see text]
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spelling pubmed-96168792022-10-30 Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA Zhang, Runjiao Zhang, Yizhou Guo, Fangzhen Huang, Guannan Zhao, Yan Chen, Bingyu Wang, Chang Cui, Chengran Shi, Yichun Li, Sha Cui, Huixian Cell Death Discov Article N6-methyladenosine (m(6)A) is abundant in the mammalian brain and is considered to have a wide range of effects on learning and memory. Here, we found that the upregulated methyltransferase-like protein 16 (METTL16) in the hippocampal tissues of Morris water maze (MWM)-trained mice contributed to improved memory formation and hippocampal synaptic plasticity. Mechanismly, METTL16 promoted the expression of methionine adenosyltransferase 2A (MAT2A) by the m(6)A methylation of the MAT2A mRNA-3′UTR-end to increase its stability, and this involved in improving hippocampal global m(6)A levels, plasticity of dendritic spine, learning and memory. This study provides a new perspective to explore the regulatory mechanisms of m(6)A for learning and memory. [Image: see text] Nature Publishing Group UK 2022-10-28 /pmc/articles/PMC9616879/ /pubmed/36307396 http://dx.doi.org/10.1038/s41420-022-01220-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhang, Runjiao
Zhang, Yizhou
Guo, Fangzhen
Huang, Guannan
Zhao, Yan
Chen, Bingyu
Wang, Chang
Cui, Chengran
Shi, Yichun
Li, Sha
Cui, Huixian
Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA
title Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA
title_full Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA
title_fullStr Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA
title_full_unstemmed Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA
title_short Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA
title_sort knockdown of mettl16 disrupts learning and memory by reducing the stability of mat2a mrna
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616879/
https://www.ncbi.nlm.nih.gov/pubmed/36307396
http://dx.doi.org/10.1038/s41420-022-01220-0
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