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Polygenic Health Index, General Health, and Pleiotropy: Sibling Analysis and Disease Risk Reduction

We construct a polygenic health index as a weighted sum of polygenic risk scores for 20 major disease conditions, including, e.g., coronary artery disease, type 1 and 2 diabetes, schizophrenia, etc. Individual weights are determined by population-level estimates of impact on life expectancy. We vali...

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Detalles Bibliográficos
Autores principales:	Widen, Erik, Lello, Louis, Raben, Timothy G., Tellier, Laurent C. A. M., Hsu, Stephen D. H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616929/ https://www.ncbi.nlm.nih.gov/pubmed/36307513 http://dx.doi.org/10.1038/s41598-022-22637-8

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