A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria

Toxin EsaD secreted by some S. aureus strains through the type VII secretion system (T7SS) specifically kills those strains lacking the antitoxin EsaG. Here we report the structures of EsaG, the nuclease domain of EsaD and their complex, which together reveal an inhibition mechanism that relies on s...

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Detalles Bibliográficos
Autores principales: Wang, Yongjin, Zhou, Yang, Shi, Chaowei, Liu, Jiacong, Lv, Guohua, Huang, Huisi, Li, Shengrong, Duan, Liping, Zheng, Xinyi, Liu, Yue, Zhou, Haibo, Wang, Yonghua, Li, Zhengqiu, Ding, Ke, Sun, Pinghua, Huang, Yun, Lu, Xiaoyun, Zhang, Zhi-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616950/
https://www.ncbi.nlm.nih.gov/pubmed/36307446
http://dx.doi.org/10.1038/s41467-022-34034-w

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