Cargando…
Investigating the regulation of the unc-33 promoter by environmental stressors
Environmental factors such as prenatal stress are hypothesized to contribute to the development of schizophrenia. Lee and colleagues determined rats exposed to prenatal stress exhibited decreased levels of only one protein, DPYSL2, in their prefrontal cortex and hippocampus. DYPSL2, a protein seen t...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Caltech Library
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617166/ https://www.ncbi.nlm.nih.gov/pubmed/36317086 http://dx.doi.org/10.17912/micropub.biology.000651 |
_version_ | 1784820781098729472 |
---|---|
author | Garcia-Gonzalez, Bianca Avant, Sarah Carassco-Pena, Angelica Miranda, Maria C Salazar, Kayley Torres, Eric Holgado, Andrea |
author_facet | Garcia-Gonzalez, Bianca Avant, Sarah Carassco-Pena, Angelica Miranda, Maria C Salazar, Kayley Torres, Eric Holgado, Andrea |
author_sort | Garcia-Gonzalez, Bianca |
collection | PubMed |
description | Environmental factors such as prenatal stress are hypothesized to contribute to the development of schizophrenia. Lee and colleagues determined rats exposed to prenatal stress exhibited decreased levels of only one protein, DPYSL2, in their prefrontal cortex and hippocampus. DYPSL2, a protein seen to be inactivated in schizophrenic patients, is important for neuronal development. The C. elegans homolog of DPYSL2, UNC-33, is also found to be critical for axonal outgrowth and synapse formation. Herein, we study the effects of environmental stressors such as increasing temperatures and pathogens on the expression of GFP driven by the unc-33 promoter. Results indicate that neuronal GFP expression was lower in C. elegans exposed to these prenatal stressors, making this the first report denoting an environmental regulation of the unc -33 promoter. This study provides insight into unc-33 and the regulation of its expression in relation to temperature and infection. |
format | Online Article Text |
id | pubmed-9617166 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Caltech Library |
record_format | MEDLINE/PubMed |
spelling | pubmed-96171662022-10-30 Investigating the regulation of the unc-33 promoter by environmental stressors Garcia-Gonzalez, Bianca Avant, Sarah Carassco-Pena, Angelica Miranda, Maria C Salazar, Kayley Torres, Eric Holgado, Andrea MicroPubl Biol New Finding Environmental factors such as prenatal stress are hypothesized to contribute to the development of schizophrenia. Lee and colleagues determined rats exposed to prenatal stress exhibited decreased levels of only one protein, DPYSL2, in their prefrontal cortex and hippocampus. DYPSL2, a protein seen to be inactivated in schizophrenic patients, is important for neuronal development. The C. elegans homolog of DPYSL2, UNC-33, is also found to be critical for axonal outgrowth and synapse formation. Herein, we study the effects of environmental stressors such as increasing temperatures and pathogens on the expression of GFP driven by the unc-33 promoter. Results indicate that neuronal GFP expression was lower in C. elegans exposed to these prenatal stressors, making this the first report denoting an environmental regulation of the unc -33 promoter. This study provides insight into unc-33 and the regulation of its expression in relation to temperature and infection. Caltech Library 2022-10-14 /pmc/articles/PMC9617166/ /pubmed/36317086 http://dx.doi.org/10.17912/micropub.biology.000651 Text en Copyright: © 2022 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | New Finding Garcia-Gonzalez, Bianca Avant, Sarah Carassco-Pena, Angelica Miranda, Maria C Salazar, Kayley Torres, Eric Holgado, Andrea Investigating the regulation of the unc-33 promoter by environmental stressors |
title |
Investigating the regulation of the
unc-33
promoter by environmental stressors
|
title_full |
Investigating the regulation of the
unc-33
promoter by environmental stressors
|
title_fullStr |
Investigating the regulation of the
unc-33
promoter by environmental stressors
|
title_full_unstemmed |
Investigating the regulation of the
unc-33
promoter by environmental stressors
|
title_short |
Investigating the regulation of the
unc-33
promoter by environmental stressors
|
title_sort | investigating the regulation of the
unc-33
promoter by environmental stressors |
topic | New Finding |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617166/ https://www.ncbi.nlm.nih.gov/pubmed/36317086 http://dx.doi.org/10.17912/micropub.biology.000651 |
work_keys_str_mv | AT garciagonzalezbianca investigatingtheregulationoftheunc33promoterbyenvironmentalstressors AT avantsarah investigatingtheregulationoftheunc33promoterbyenvironmentalstressors AT carasscopenaangelica investigatingtheregulationoftheunc33promoterbyenvironmentalstressors AT mirandamariac investigatingtheregulationoftheunc33promoterbyenvironmentalstressors AT salazarkayley investigatingtheregulationoftheunc33promoterbyenvironmentalstressors AT torreseric investigatingtheregulationoftheunc33promoterbyenvironmentalstressors AT holgadoandrea investigatingtheregulationoftheunc33promoterbyenvironmentalstressors |