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Influencing factors of biliary fistula after radical resection of hilar cholangiocarcinoma: a prospect cohort

BACKGROUND: Biliary fistula is a common but serious complication after radical resection of hilar cholangiocarcinoma. We aimed to evaluate the influencing factors of biliary fistula after radical resection, to provide insights to the clinical treatment of hilar cholangiocarcinoma. METHODS: Patients...

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Autores principales: Zhang, Dengyong, Qi, Feiyu, Sun, Wanliang, Zhao, Guanru, Wang, Dongdong, Zhou, Shuo, Liu, Zhong, Lu, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617426/
https://www.ncbi.nlm.nih.gov/pubmed/36307886
http://dx.doi.org/10.1186/s40001-022-00851-4
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author Zhang, Dengyong
Qi, Feiyu
Sun, Wanliang
Zhao, Guanru
Wang, Dongdong
Zhou, Shuo
Liu, Zhong
Lu, Zheng
author_facet Zhang, Dengyong
Qi, Feiyu
Sun, Wanliang
Zhao, Guanru
Wang, Dongdong
Zhou, Shuo
Liu, Zhong
Lu, Zheng
author_sort Zhang, Dengyong
collection PubMed
description BACKGROUND: Biliary fistula is a common but serious complication after radical resection of hilar cholangiocarcinoma. We aimed to evaluate the influencing factors of biliary fistula after radical resection, to provide insights to the clinical treatment of hilar cholangiocarcinoma. METHODS: Patients undergoing radical resection of hilar cholangiocarcinoma from January 1, 2015 to March 31, 2022 were selected. Patients’ personnel characteristics and laboratory test results of patients with and without biliary fistula were collected and compared. Logistic regression analyses were conducted to evaluate the associated risk factors of biliary fistula. RESULTS: 160 patients undergoing radical resection of hilar cholangiocarcinoma were included, the incidence of postoperative biliary fistulas was 20.63%. There were significant differences in the age, preoperative cholangitis and number of biliary anastomosis between biliary fistula and no biliary fistula patients (all p < 0.05). There were significant differences in the gamma glutamyl transpeptidase (GGT) on the first day after surgery, Klebsiella pneumoniae between biliary fistula and no biliary fistula patients (all p < 0.05). Logistic regression analysis indicated that age ≥ 65 years (OR  2.035, 95%CI 1.131–3.007), preoperative cholangitis (OR 1.584, 95% CI 1.081–2.361), number of biliary anastomosis ≥ 2(OR 2.866, 95%CI 1.942–3.624), GGT on the first day after surgery ≥ 120 U/L (OR 1.823, 95%CI: 1.274–2.906), preoperative bile culture for Klebsiella pneumoniae (OR 3.181, 95%CI: 2.426–3.992) were the risk factors of postoperative biliary fistulas (all p < 0.05). CONCLUSIONS: There are many independent risk factors for postoperative biliary fistula in patients undergoing radical resection of hilar cholangiocarcinoma. Clinical medical workers should take early interventions and treatment measures for these high-risk patients to reduce the occurrence of postoperative biliary fistula.
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spelling pubmed-96174262022-10-30 Influencing factors of biliary fistula after radical resection of hilar cholangiocarcinoma: a prospect cohort Zhang, Dengyong Qi, Feiyu Sun, Wanliang Zhao, Guanru Wang, Dongdong Zhou, Shuo Liu, Zhong Lu, Zheng Eur J Med Res Research BACKGROUND: Biliary fistula is a common but serious complication after radical resection of hilar cholangiocarcinoma. We aimed to evaluate the influencing factors of biliary fistula after radical resection, to provide insights to the clinical treatment of hilar cholangiocarcinoma. METHODS: Patients undergoing radical resection of hilar cholangiocarcinoma from January 1, 2015 to March 31, 2022 were selected. Patients’ personnel characteristics and laboratory test results of patients with and without biliary fistula were collected and compared. Logistic regression analyses were conducted to evaluate the associated risk factors of biliary fistula. RESULTS: 160 patients undergoing radical resection of hilar cholangiocarcinoma were included, the incidence of postoperative biliary fistulas was 20.63%. There were significant differences in the age, preoperative cholangitis and number of biliary anastomosis between biliary fistula and no biliary fistula patients (all p < 0.05). There were significant differences in the gamma glutamyl transpeptidase (GGT) on the first day after surgery, Klebsiella pneumoniae between biliary fistula and no biliary fistula patients (all p < 0.05). Logistic regression analysis indicated that age ≥ 65 years (OR  2.035, 95%CI 1.131–3.007), preoperative cholangitis (OR 1.584, 95% CI 1.081–2.361), number of biliary anastomosis ≥ 2(OR 2.866, 95%CI 1.942–3.624), GGT on the first day after surgery ≥ 120 U/L (OR 1.823, 95%CI: 1.274–2.906), preoperative bile culture for Klebsiella pneumoniae (OR 3.181, 95%CI: 2.426–3.992) were the risk factors of postoperative biliary fistulas (all p < 0.05). CONCLUSIONS: There are many independent risk factors for postoperative biliary fistula in patients undergoing radical resection of hilar cholangiocarcinoma. Clinical medical workers should take early interventions and treatment measures for these high-risk patients to reduce the occurrence of postoperative biliary fistula. BioMed Central 2022-10-28 /pmc/articles/PMC9617426/ /pubmed/36307886 http://dx.doi.org/10.1186/s40001-022-00851-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zhang, Dengyong
Qi, Feiyu
Sun, Wanliang
Zhao, Guanru
Wang, Dongdong
Zhou, Shuo
Liu, Zhong
Lu, Zheng
Influencing factors of biliary fistula after radical resection of hilar cholangiocarcinoma: a prospect cohort
title Influencing factors of biliary fistula after radical resection of hilar cholangiocarcinoma: a prospect cohort
title_full Influencing factors of biliary fistula after radical resection of hilar cholangiocarcinoma: a prospect cohort
title_fullStr Influencing factors of biliary fistula after radical resection of hilar cholangiocarcinoma: a prospect cohort
title_full_unstemmed Influencing factors of biliary fistula after radical resection of hilar cholangiocarcinoma: a prospect cohort
title_short Influencing factors of biliary fistula after radical resection of hilar cholangiocarcinoma: a prospect cohort
title_sort influencing factors of biliary fistula after radical resection of hilar cholangiocarcinoma: a prospect cohort
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617426/
https://www.ncbi.nlm.nih.gov/pubmed/36307886
http://dx.doi.org/10.1186/s40001-022-00851-4
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