Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy

Myasthenia gravis (MG) is an autoantibody-mediated autoimmune disorder of the neuromuscular junction. A small subset of patients (<10%) with MG, have autoantibodies targeting muscle-specific tyrosine kinase (MuSK). MuSK MG patients respond well to CD20-mediated B cell depletion therapy (BCDT); mo...

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Detalles Bibliográficos
Autores principales: Fichtner, Miriam L., Hoehn, Kenneth B., Ford, Easton E., Mane-Damas, Marina, Oh, Sangwook, Waters, Patrick, Payne, Aimee S., Smith, Melissa L., Watson, Corey T., Losen, Mario, Martinez-Martinez, Pilar, Nowak, Richard J., Kleinstein, Steven H., O’Connor, Kevin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617453/
https://www.ncbi.nlm.nih.gov/pubmed/36307868
http://dx.doi.org/10.1186/s40478-022-01454-0

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