Cargando…

Evaluation of Molecular Properties versus In Vivo Performance of Aflibercept, Brolucizumab, and Ranibizumab in a Retinal Vascular Hyperpermeability Model

PURPOSE: To evaluate the molecular, pharmacokinetic, and pharmacological properties of three anti-vascular endothelial growth factor (VEGF) agents—aflibercept, brolucizumab, and ranibizumab—and to provide a prediction of the optimal design of an intravitreal VEGF challenge in rabbits to assess the p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schubert, William, Terjung, Carsten, Rafique, Ashique, Romano, Carmelo, Ellinger, Philipp, Rittenhouse, Kay D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2022
Materias:	Retina
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617509/ https://www.ncbi.nlm.nih.gov/pubmed/36282118 http://dx.doi.org/10.1167/tvst.11.10.36

Ejemplares similares

Aflibercept Suppression of Angiopoietin-2 in a Rabbit Retinal Vascular Hyperpermeability Model
por: Lange, Claudia, et al.
Publicado: (2023)

Aflibercept Suppression of Angiopoietin-2 in a Rabbit Retinal Vascular Hyperpermeability Model
por: Lange, Claudia, et al.
Publicado: (2023)

Choroidal Vein Alterations in Pachychoroid Disease With Choroidal Vascular Hyperpermeability: Evaluated by Wide-Field Indocyanine Green Angiography
por: He, Guiqin, et al.
Publicado: (2023)

Functional benefits of a chorioretinal anastomosis at 2 years in eyes with a central retinal vein occlusion treated with ranibizumab compared with ranibizumab monotherapy
por: McAllister, Ian L, et al.
Publicado: (2021)

Durability of VEGF Suppression With Intravitreal Aflibercept and Brolucizumab: Using Pharmacokinetic Modeling to Understand Clinical Outcomes
por: Eissing, Thomas, et al.
Publicado: (2021)

Systematic review of efficacy and meta-analysis of safety of ranibizumab biosimilars relative to reference ranibizumab anti-VEGF therapy for nAMD treatment
por: Hatamnejad, Amin, et al.
Publicado: (2023)

Brolucizumab vs aflibercept and ranibizumab for neovascular age-related macular degeneration: a cost-effectiveness analysis
por: Yu, Justin S, et al.
Publicado: (2021)

Retinal Vascular Plexuses Are Unequally Affected in Canine Inherited Retinal Degenerations
por: Ripolles-Garcia, Ana, et al.
Publicado: (2022)

Retinal Vascular Branching in Healthy and Diabetic Subjects
por: Luo, Ting, et al.
Publicado: (2017)

Retinal Vascular Oxygen Saturation in Adults With Anisometropia
por: Ge, Shanshan, et al.
Publicado: (2023)

Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes
por: Liu, Haitao, et al.
Publicado: (2016)

Mechanistic Evaluation of Panretinal Photocoagulation Versus Aflibercept in Proliferative Diabetic Retinopathy: CLARITY Substudy
por: Nicholson, Luke, et al.
Publicado: (2018)

Randomized Trial of Treat-and-Extend Intravitreal Aflibercept for Radiation Retinopathy: 1-Year Outcomes
por: Trejo Corona, Stephanie, et al.
Publicado: (2023)

Association of Systemic Inflammation With Retinal Vascular Caliber in Patients With AIDS
por: Jabs, Douglas A., et al.
Publicado: (2019)

Preclinical Efficacy and Safety of VEGF-Grab, a Novel Anti-VEGF Drug, and Its Comparison to Aflibercept
por: Hong, Hye Kyoung, et al.
Publicado: (2020)

In Vivo Imaging of Retinal and Choroidal Morphology and Vascular Plexuses of Vertebrates Using Swept-Source Optical Coherence Tomography
por: Meleppat, Ratheesh K., et al.
Publicado: (2022)

Retinal Vascular and Oxygen Temporal Dynamic Responses to Light Flicker in Humans
por: Felder, Anthony E., et al.
Publicado: (2017)

All-trans-Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion
por: Dreffs, Alyssa, et al.
Publicado: (2020)

Retinal Vascular Oxygen Saturation in a Sample of Chinese Myopic Adults
por: Ge, Shanshan, et al.
Publicado: (2023)

Plasma Kallikrein Mediates Vascular Endothelial Growth Factor–Induced Retinal Dysfunction and Thickening
por: Clermont, Allen, et al.
Publicado: (2016)

Switching to Brolucizumab in Neovascular Age-Related Macular Degeneration Incompletely Responsive to Ranibizumab or Aflibercept: Real-Life 6 Month Outcomes
por: Haensli, Christof, et al.
Publicado: (2021)

Association of Retinal Vascular Caliber and Age-Related Macular Degeneration in Patients With the Acquired Immunodeficiency Syndrome
por: Jabs, Douglas A., et al.
Publicado: (2018)

Approach for a Clinically Useful Comprehensive Classification of Vascular and Neural Aspects of Diabetic Retinal Disease
por: Abramoff, Michael D., et al.
Publicado: (2018)

Deep learning-based classification of retinal vascular diseases using ultra-widefield colour fundus photographs
por: Abitbol, Elie, et al.
Publicado: (2022)

Comparison of intravitreal injection of ranibizumab versus bevacizumab for treatment of type 1 and aggressive retinopathy of prematurity in rural Egypt. A randomized clinical trial
por: Tawfik, Ghada Mahmoud, et al.
Publicado: (2022)

Radial Peripapillary Capillary Plexus Sparing and Underlying Retinal Vascular Impairment in Intermediate Age-Related Macular Degeneration
por: Trinh, Matt, et al.
Publicado: (2021)

MicroRNA-92a-3p Regulates Retinal Angiogenesis by Targeting SGK3 in Vascular Endothelial Cells
por: Cui, Yamei, et al.
Publicado: (2022)

Retinal Vascular Changes in Alzheimer's Dementia and Mild Cognitive Impairment: A Pilot Study Using Ultra-Widefield Imaging
por: Pead, Emma, et al.
Publicado: (2023)

In Vivo Imaging of Retinal Hypoxia Using HYPOX-4-Dependent Fluorescence in a Mouse Model of Laser-Induced Retinal Vein Occlusion (RVO)
por: Uddin, Md. Imam, et al.
Publicado: (2017)

Brolucizumab-related retinal vasculitis with exacerbation following ranibizumab retreatment: A clinicopathologic case study
por: Iyer, Prashanth G., et al.
Publicado: (2020)

In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode–Based Retinal Prosthesis
por: Bosse, Brandon, et al.
Publicado: (2018)

Assessment of Murine Retinal Acuity Ex Vivo Using Multielectrode Array Recordings
por: Babino, Darwin, et al.
Publicado: (2023)

Comparison of the regressive effects of aflibercept and brolucizumab on pigment epithelial detachment
por: Mukai, Ryo, et al.
Publicado: (2022)

Assessing Photoreceptor Structure in Retinitis Pigmentosa and Usher Syndrome
por: Sun, Lynn W., et al.
Publicado: (2016)

Changes in Retinal Vessel and Retinal Layer Thickness After Vitrectomy in Retinal Detachment via Swept-Source OCT Angiography
por: Hong, Eun Hee, et al.
Publicado: (2020)

Cone Spacing Correlates With Retinal Thickness and Microperimetry in Patients With Inherited Retinal Degenerations
por: Foote, Katharina G., et al.
Publicado: (2019)

Morphological Analysis of Retinal Microvasculature to Improve Understanding of Retinal Hemorrhage Mechanics in Infants
por: Byrne, Matt P., et al.
Publicado: (2020)

EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development
por: Cao, Xiaowen, et al.
Publicado: (2021)

Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime
por: Seifert, Eric, et al.
Publicado: (2021)

Outer Retinal Oxidative Stress Measured In Vivo Using QUEnch-assiSTed (QUEST) OCT
por: Berkowitz, Bruce A., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0t5dbn16v33i3o89mi5dqhn3fk