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E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance

Prevention or amelioration of declining β cell mass is a potential strategy to cure diabetes. Here, we report the pathways utilized by β cells to robustly replicate in response to acute insulin resistance induced by S961, a pharmacological insulin receptor antagonist. Interestingly, pathways that in...

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Detalles Bibliográficos
Autores principales:	Shirakawa, Jun, Togashi, Yu, Basile, Giorgio, Okuyama, Tomoko, Inoue, Ryota, Fernandez, Megan, Kyohara, Mayu, De Jesus, Dario F., Goto, Nozomi, Zhang, Wei, Tsuno, Takahiro, Kin, Tatsuya, Pan, Hui, Dreyfuss, Jonathan M., Shapiro, A.M. James, Yi, Peng, Terauchi, Yasuo, Kulkarni, Rohit N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617565/ https://www.ncbi.nlm.nih.gov/pubmed/36198264 http://dx.doi.org/10.1016/j.celrep.2022.111436

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