High Intrapulmonary Rifampicin and Isoniazid Concentrations Are Associated With Rapid Sputum Bacillary Clearance in Patients With Pulmonary Tuberculosis( )

BACKGROUND: Intrapulmonary pharmacokinetics may better explain response to tuberculosis (TB) treatment than plasma pharmacokinetics. We explored these relationships by modeling bacillary clearance in sputum in adult patients on first-line treatment in Malawi. METHODS: Bacillary elimination rates (BE...

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Detalles Bibliográficos
Autores principales: McCallum, Andrew D, Pertinez, Henry E, Chirambo, Aaron P, Sheha, Irene, Chasweka, Madalitso, Malamba, Rose, Shani, Doris, Chitani, Alex, Mallewa, Jane E, Meghji, Jamilah Z, Ghany, Jehan F, Corbett, Elizabeth L, Gordon, Stephen B, Davies, Geraint R, Khoo, Saye H, Sloan, Derek J, Mwandumba, Henry C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Major Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617580/
https://www.ncbi.nlm.nih.gov/pubmed/35325074
http://dx.doi.org/10.1093/cid/ciac228

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