History of Previous Midlife Estradiol Treatment Permanently Alters Interactions of Brain Insulin-like Growth Factor-1 Signaling and Hippocampal Estrogen Synthesis to Enhance Cognitive Aging in a Rat Model of Menopause

Across species, including humans, elevated levels of brain estrogen receptor (ER) α are associated with enhanced cognitive aging, even in the absence of circulating estrogens. In rodents, short-term estrogen treatment, such as that commonly used in the menopausal transition, results in long-term inc...

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Detalles Bibliográficos
Autores principales: Baumgartner, Nina E., McQuillen, Shannon M., Perry, Samantha F., Miller, Sangtawan, Maroteaux, Matthieu J., Gibbs, Robert B., Daniel, Jill M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617614/
https://www.ncbi.nlm.nih.gov/pubmed/36261268
http://dx.doi.org/10.1523/JNEUROSCI.0588-22.2022

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