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Alveolar Proteinosis in COVID-19: Clinical Case
Pulmonary alveolar proteinosis (PAP) is a rare, diffuse lung disease characterized by accumulation of lipoprotein in lung surfactant in the alveolar space and terminal bronchioles, leading to impaired gas exchange and arterial hypoxemia. We present the case of a 51-year-old woman who was admitted wi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617725/ https://www.ncbi.nlm.nih.gov/pubmed/36317156 http://dx.doi.org/10.1155/2022/1842566 |
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author | Martin Bote, Silvia Herrera Morueco, Maria Angeles Arias Arcos, Beatriz García Lopez, Javier Lopez-Muñiz Ballesteros, Maria Belen |
author_facet | Martin Bote, Silvia Herrera Morueco, Maria Angeles Arias Arcos, Beatriz García Lopez, Javier Lopez-Muñiz Ballesteros, Maria Belen |
author_sort | Martin Bote, Silvia |
collection | PubMed |
description | Pulmonary alveolar proteinosis (PAP) is a rare, diffuse lung disease characterized by accumulation of lipoprotein in lung surfactant in the alveolar space and terminal bronchioles, leading to impaired gas exchange and arterial hypoxemia. We present the case of a 51-year-old woman who was admitted with a diagnosis of severe SARS-CoV-2 pneumonia. Her condition did not improve with corticosteroids. A chest CT scan revealed ground-glass opacities in all lung lobes, with septal thickening. A differential diagnosis was proposed with other diseases. Bronchoscopy revealed milky bronchoalveolar lavage fluid, and staining with periodic acid–Schiff was positive, thus indicating PAP. Therefore, the patient underwent whole lung lavage, which led to clinical, radiological, and functional improvement. In the context of the COVID-19 pandemic, differential diagnosis ensures that appropriate attention is given to less prevalent entities such as PAP. |
format | Online Article Text |
id | pubmed-9617725 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-96177252022-10-30 Alveolar Proteinosis in COVID-19: Clinical Case Martin Bote, Silvia Herrera Morueco, Maria Angeles Arias Arcos, Beatriz García Lopez, Javier Lopez-Muñiz Ballesteros, Maria Belen Case Rep Pulmonol Case Report Pulmonary alveolar proteinosis (PAP) is a rare, diffuse lung disease characterized by accumulation of lipoprotein in lung surfactant in the alveolar space and terminal bronchioles, leading to impaired gas exchange and arterial hypoxemia. We present the case of a 51-year-old woman who was admitted with a diagnosis of severe SARS-CoV-2 pneumonia. Her condition did not improve with corticosteroids. A chest CT scan revealed ground-glass opacities in all lung lobes, with septal thickening. A differential diagnosis was proposed with other diseases. Bronchoscopy revealed milky bronchoalveolar lavage fluid, and staining with periodic acid–Schiff was positive, thus indicating PAP. Therefore, the patient underwent whole lung lavage, which led to clinical, radiological, and functional improvement. In the context of the COVID-19 pandemic, differential diagnosis ensures that appropriate attention is given to less prevalent entities such as PAP. Hindawi 2022-10-22 /pmc/articles/PMC9617725/ /pubmed/36317156 http://dx.doi.org/10.1155/2022/1842566 Text en Copyright © 2022 Silvia Martin Bote et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Martin Bote, Silvia Herrera Morueco, Maria Angeles Arias Arcos, Beatriz García Lopez, Javier Lopez-Muñiz Ballesteros, Maria Belen Alveolar Proteinosis in COVID-19: Clinical Case |
title | Alveolar Proteinosis in COVID-19: Clinical Case |
title_full | Alveolar Proteinosis in COVID-19: Clinical Case |
title_fullStr | Alveolar Proteinosis in COVID-19: Clinical Case |
title_full_unstemmed | Alveolar Proteinosis in COVID-19: Clinical Case |
title_short | Alveolar Proteinosis in COVID-19: Clinical Case |
title_sort | alveolar proteinosis in covid-19: clinical case |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617725/ https://www.ncbi.nlm.nih.gov/pubmed/36317156 http://dx.doi.org/10.1155/2022/1842566 |
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