Daptomycin-Related Rhabdomyolysis Complicated by Severe Hyperkalemia and Acute Kidney Injury

We describe a case of a 65-year-old man who presented with progressive generalized weakness. He was started on daptomycin for methicillin-resistant Staphylococcus aureus (MRSA) right fifth metatarsal osteomyelitis. Laboratory testing revealed severe hyperkalemia of 7.5 mEq/L (normal range: 3.3-5.1)...

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Detalles Bibliográficos
Autor principal: Nishimura, Yoshito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Emergency Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617813/
https://www.ncbi.nlm.nih.gov/pubmed/36324366
http://dx.doi.org/10.7759/cureus.29764
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author Nishimura, Yoshito
author_facet Nishimura, Yoshito
author_sort Nishimura, Yoshito
collection PubMed
description We describe a case of a 65-year-old man who presented with progressive generalized weakness. He was started on daptomycin for methicillin-resistant Staphylococcus aureus (MRSA) right fifth metatarsal osteomyelitis. Laboratory testing revealed severe hyperkalemia of 7.5 mEq/L (normal range: 3.3-5.1) and acute kidney injury (AKI) stage 1 associated with a substantial elevation in serum creatine kinase (CK). He had been on a high-intensity statin for years, and daptomycin was switched to linezolid, and statin was held as daptomycin-related rhabdomyolysis was suspected. Our case highlights the importance of seeking alternatives to daptomycin for patients on chronic statins.
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spelling pubmed-96178132022-11-01 Daptomycin-Related Rhabdomyolysis Complicated by Severe Hyperkalemia and Acute Kidney Injury Nishimura, Yoshito Cureus Emergency Medicine We describe a case of a 65-year-old man who presented with progressive generalized weakness. He was started on daptomycin for methicillin-resistant Staphylococcus aureus (MRSA) right fifth metatarsal osteomyelitis. Laboratory testing revealed severe hyperkalemia of 7.5 mEq/L (normal range: 3.3-5.1) and acute kidney injury (AKI) stage 1 associated with a substantial elevation in serum creatine kinase (CK). He had been on a high-intensity statin for years, and daptomycin was switched to linezolid, and statin was held as daptomycin-related rhabdomyolysis was suspected. Our case highlights the importance of seeking alternatives to daptomycin for patients on chronic statins. Cureus 2022-09-29 /pmc/articles/PMC9617813/ /pubmed/36324366 http://dx.doi.org/10.7759/cureus.29764 Text en Copyright © 2022, Nishimura et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Emergency Medicine
Nishimura, Yoshito
Daptomycin-Related Rhabdomyolysis Complicated by Severe Hyperkalemia and Acute Kidney Injury
title Daptomycin-Related Rhabdomyolysis Complicated by Severe Hyperkalemia and Acute Kidney Injury
title_full Daptomycin-Related Rhabdomyolysis Complicated by Severe Hyperkalemia and Acute Kidney Injury
title_fullStr Daptomycin-Related Rhabdomyolysis Complicated by Severe Hyperkalemia and Acute Kidney Injury
title_full_unstemmed Daptomycin-Related Rhabdomyolysis Complicated by Severe Hyperkalemia and Acute Kidney Injury
title_short Daptomycin-Related Rhabdomyolysis Complicated by Severe Hyperkalemia and Acute Kidney Injury
title_sort daptomycin-related rhabdomyolysis complicated by severe hyperkalemia and acute kidney injury
topic Emergency Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617813/
https://www.ncbi.nlm.nih.gov/pubmed/36324366
http://dx.doi.org/10.7759/cureus.29764
work_keys_str_mv AT nishimurayoshito daptomycinrelatedrhabdomyolysiscomplicatedbyseverehyperkalemiaandacutekidneyinjury

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