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EGFL7 drives the evolution of resistance to EGFR inhibitors in lung cancer by activating NOTCH signaling

Accumulating evidence supports evolutionary trait of drug resistance. Like resilience in other systems, most tumor cells experience drug-tolerant state before full resistance acquired. However, the underlying mechanism is still poorly understood. Here, we identify that EGF like domain multiple 7 (EG...

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Detalles Bibliográficos
Autores principales:	Wang, Yubo, Chen, Pu, Zhao, Man, Cao, Hongxin, Zhao, Yuelei, Ji, Meiju, Hou, Peng, Chen, Mingwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617940/ https://www.ncbi.nlm.nih.gov/pubmed/36309484 http://dx.doi.org/10.1038/s41419-022-05354-y

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