Cargando…
Associations between urban birth or childhood trauma and first-episode schizophrenia mediated by low IQ
Exposure to urban birth, childhood trauma, and lower Intelligence Quotient (IQ) were the most well-established risk factors for schizophrenia in developed countries. In developing countries, whether urban birth is a risk factor for schizophrenia and how these factors are related to one another remai...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617944/ https://www.ncbi.nlm.nih.gov/pubmed/36309513 http://dx.doi.org/10.1038/s41537-022-00289-x |
_version_ | 1784820945723064320 |
---|---|
author | Xie, Min Zhao, Zhengyang Dai, Minhan Wu, Yulu Huang, Yunqi Liu, Yunjia Tang, Yiguo Xiao, Liling Wei, Wei Zhang, Guangya Du, Xiangdong Li, Chuanwei Guo, Wanjun Ma, Xiaohong Deng, Wei Wang, Qiang Li, Tao |
author_facet | Xie, Min Zhao, Zhengyang Dai, Minhan Wu, Yulu Huang, Yunqi Liu, Yunjia Tang, Yiguo Xiao, Liling Wei, Wei Zhang, Guangya Du, Xiangdong Li, Chuanwei Guo, Wanjun Ma, Xiaohong Deng, Wei Wang, Qiang Li, Tao |
author_sort | Xie, Min |
collection | PubMed |
description | Exposure to urban birth, childhood trauma, and lower Intelligence Quotient (IQ) were the most well-established risk factors for schizophrenia in developed countries. In developing countries, whether urban birth is a risk factor for schizophrenia and how these factors are related to one another remain unclear. This study aimed to investigate whether IQ mediates the relationship between urban birth or childhood trauma and first-episode schizophrenia (FES) in China. Birthplace, childhood trauma questionnaire (CTQ), and IQ were collected from 144 patients with FES and 256 healthy controls (HCs). Hierarchical logistic regression analysis was conducted to investigate the associations between birthplace, childhood trauma, IQ, and FES. Furthermore, mediation analysis was used to explore the mediation of IQ in the relationship between birthplace or childhood trauma and FES. After adjusting for age, sex and educational attainment, the final model identified urban birth (odds ratio (OR) = 3.15, 95% CI = 1.54, 6.44) and childhood trauma (OR = 2.79, 95% CI = 1.92, 4.06) were associated an elevated risk for FES. The 52.94% total effect of birthplace on the risk of FES could be offset by IQ (indirect effect/direct effect). The association between childhood trauma and FES could be partly explained by IQ (22.5%). In total, the mediation model explained 70.5% of the total variance in FES. Our study provides evidence that urban birth and childhood trauma are associated with an increased risk of FES. Furthermore, IQ mediates the relationship between urban birth or childhood trauma and FES. |
format | Online Article Text |
id | pubmed-9617944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-96179442022-10-31 Associations between urban birth or childhood trauma and first-episode schizophrenia mediated by low IQ Xie, Min Zhao, Zhengyang Dai, Minhan Wu, Yulu Huang, Yunqi Liu, Yunjia Tang, Yiguo Xiao, Liling Wei, Wei Zhang, Guangya Du, Xiangdong Li, Chuanwei Guo, Wanjun Ma, Xiaohong Deng, Wei Wang, Qiang Li, Tao Schizophrenia (Heidelb) Article Exposure to urban birth, childhood trauma, and lower Intelligence Quotient (IQ) were the most well-established risk factors for schizophrenia in developed countries. In developing countries, whether urban birth is a risk factor for schizophrenia and how these factors are related to one another remain unclear. This study aimed to investigate whether IQ mediates the relationship between urban birth or childhood trauma and first-episode schizophrenia (FES) in China. Birthplace, childhood trauma questionnaire (CTQ), and IQ were collected from 144 patients with FES and 256 healthy controls (HCs). Hierarchical logistic regression analysis was conducted to investigate the associations between birthplace, childhood trauma, IQ, and FES. Furthermore, mediation analysis was used to explore the mediation of IQ in the relationship between birthplace or childhood trauma and FES. After adjusting for age, sex and educational attainment, the final model identified urban birth (odds ratio (OR) = 3.15, 95% CI = 1.54, 6.44) and childhood trauma (OR = 2.79, 95% CI = 1.92, 4.06) were associated an elevated risk for FES. The 52.94% total effect of birthplace on the risk of FES could be offset by IQ (indirect effect/direct effect). The association between childhood trauma and FES could be partly explained by IQ (22.5%). In total, the mediation model explained 70.5% of the total variance in FES. Our study provides evidence that urban birth and childhood trauma are associated with an increased risk of FES. Furthermore, IQ mediates the relationship between urban birth or childhood trauma and FES. Nature Publishing Group UK 2022-10-29 /pmc/articles/PMC9617944/ /pubmed/36309513 http://dx.doi.org/10.1038/s41537-022-00289-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Xie, Min Zhao, Zhengyang Dai, Minhan Wu, Yulu Huang, Yunqi Liu, Yunjia Tang, Yiguo Xiao, Liling Wei, Wei Zhang, Guangya Du, Xiangdong Li, Chuanwei Guo, Wanjun Ma, Xiaohong Deng, Wei Wang, Qiang Li, Tao Associations between urban birth or childhood trauma and first-episode schizophrenia mediated by low IQ |
title | Associations between urban birth or childhood trauma and first-episode schizophrenia mediated by low IQ |
title_full | Associations between urban birth or childhood trauma and first-episode schizophrenia mediated by low IQ |
title_fullStr | Associations between urban birth or childhood trauma and first-episode schizophrenia mediated by low IQ |
title_full_unstemmed | Associations between urban birth or childhood trauma and first-episode schizophrenia mediated by low IQ |
title_short | Associations between urban birth or childhood trauma and first-episode schizophrenia mediated by low IQ |
title_sort | associations between urban birth or childhood trauma and first-episode schizophrenia mediated by low iq |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617944/ https://www.ncbi.nlm.nih.gov/pubmed/36309513 http://dx.doi.org/10.1038/s41537-022-00289-x |
work_keys_str_mv | AT xiemin associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq AT zhaozhengyang associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq AT daiminhan associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq AT wuyulu associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq AT huangyunqi associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq AT liuyunjia associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq AT tangyiguo associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq AT xiaoliling associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq AT weiwei associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq AT zhangguangya associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq AT duxiangdong associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq AT lichuanwei associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq AT guowanjun associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq AT maxiaohong associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq AT dengwei associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq AT wangqiang associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq AT litao associationsbetweenurbanbirthorchildhoodtraumaandfirstepisodeschizophreniamediatedbylowiq |