Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma

Glioblastoma (GBM) is notorious for its immunosuppressive tumor microenvironment (TME) and is refractory to immune checkpoint blockade (ICB). Here, we identify calmodulin-dependent kinase kinase 2 (CaMKK2) as a driver of ICB resistance. CaMKK2 is highly expressed in pro-tumor cells and is associated...

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Detalles Bibliográficos
Autores principales: Tomaszewski, William H., Waibl-Polania, Jessica, Chakraborty, Molly, Perera, Jonathan, Ratiu, Jeremy, Miggelbrink, Alexandra, McDonnell, Donald P., Khasraw, Mustafa, Ashley, David M., Fecci, Peter E., Racioppi, Luigi, Sanchez-Perez, Luis, Gunn, Michael D., Sampson, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617949/
https://www.ncbi.nlm.nih.gov/pubmed/36309495
http://dx.doi.org/10.1038/s41467-022-34175-y

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