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Changes of macular blood flow and structure in acute primary angle closure glaucoma

PURPOSE: We assessed the relationship between acute primary angle closure glaucoma (APACG) severity and macular microcirculation, as well as the diagnostic ability of blood flow and macular structural parameters on optical coherence tomography angiography (OCTA) for APACG. METHODS: APACG patients we...

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Autores principales: Wang, Rui, Yang, Jin, Shi, Liukun, Qu, Yue, Xu, Dan, Liu, Yufeng, Li, Xuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617959/
https://www.ncbi.nlm.nih.gov/pubmed/35781598
http://dx.doi.org/10.1007/s10792-022-02399-y
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author Wang, Rui
Yang, Jin
Shi, Liukun
Qu, Yue
Xu, Dan
Liu, Yufeng
Li, Xuan
author_facet Wang, Rui
Yang, Jin
Shi, Liukun
Qu, Yue
Xu, Dan
Liu, Yufeng
Li, Xuan
author_sort Wang, Rui
collection PubMed
description PURPOSE: We assessed the relationship between acute primary angle closure glaucoma (APACG) severity and macular microcirculation, as well as the diagnostic ability of blood flow and macular structural parameters on optical coherence tomography angiography (OCTA) for APACG. METHODS: APACG patients were assigned to mild, moderate, and severe groups in this cross-sectional study. Age-matched primary angle closure suspect (PACS) and healthy control groups were also recruited. The vessel density (VD) and foveal avascular zone (FAZ) in each macular superficial area were measured using OCTA. The retinal nerve fiber layer thickness (RNFLT) and ganglion cell complex thickness (GCCT) of the corresponding regions were measured using OCT. RESULTS: All parameters in the control, PACS, and mild APACG groups differed significantly from those in the moderate and severe APACG groups (all P < 0.05). VD and RNFLT showed high and moderate diagnostic ability, respectively, to distinguish moderate APACG from PACS, with significant differences (P < 0.05) in areas under the receiver operating characteristic curve (AUCs) for VD and RNFLT in six macular areas. The diagnostic abilities of VD and RNFLT for distinguishing severe APACG from PACS were increased, with significant differences in the AUCs for VD and RNFLT in five macular areas (P < 0.05). All macular VDs and GCCTs were similar among the three APACG groups (P > 0.05). CONCLUSIONS: Damage to the VD and FAZ in the macula increased with APACG severity. VD in the macular superficial layer showed a higher diagnostic ability than RNFLT, which was equivalent to that of GCCT.
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spelling pubmed-96179592022-10-31 Changes of macular blood flow and structure in acute primary angle closure glaucoma Wang, Rui Yang, Jin Shi, Liukun Qu, Yue Xu, Dan Liu, Yufeng Li, Xuan Int Ophthalmol Original Paper PURPOSE: We assessed the relationship between acute primary angle closure glaucoma (APACG) severity and macular microcirculation, as well as the diagnostic ability of blood flow and macular structural parameters on optical coherence tomography angiography (OCTA) for APACG. METHODS: APACG patients were assigned to mild, moderate, and severe groups in this cross-sectional study. Age-matched primary angle closure suspect (PACS) and healthy control groups were also recruited. The vessel density (VD) and foveal avascular zone (FAZ) in each macular superficial area were measured using OCTA. The retinal nerve fiber layer thickness (RNFLT) and ganglion cell complex thickness (GCCT) of the corresponding regions were measured using OCT. RESULTS: All parameters in the control, PACS, and mild APACG groups differed significantly from those in the moderate and severe APACG groups (all P < 0.05). VD and RNFLT showed high and moderate diagnostic ability, respectively, to distinguish moderate APACG from PACS, with significant differences (P < 0.05) in areas under the receiver operating characteristic curve (AUCs) for VD and RNFLT in six macular areas. The diagnostic abilities of VD and RNFLT for distinguishing severe APACG from PACS were increased, with significant differences in the AUCs for VD and RNFLT in five macular areas (P < 0.05). All macular VDs and GCCTs were similar among the three APACG groups (P > 0.05). CONCLUSIONS: Damage to the VD and FAZ in the macula increased with APACG severity. VD in the macular superficial layer showed a higher diagnostic ability than RNFLT, which was equivalent to that of GCCT. Springer Netherlands 2022-07-04 2022 /pmc/articles/PMC9617959/ /pubmed/35781598 http://dx.doi.org/10.1007/s10792-022-02399-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Wang, Rui
Yang, Jin
Shi, Liukun
Qu, Yue
Xu, Dan
Liu, Yufeng
Li, Xuan
Changes of macular blood flow and structure in acute primary angle closure glaucoma
title Changes of macular blood flow and structure in acute primary angle closure glaucoma
title_full Changes of macular blood flow and structure in acute primary angle closure glaucoma
title_fullStr Changes of macular blood flow and structure in acute primary angle closure glaucoma
title_full_unstemmed Changes of macular blood flow and structure in acute primary angle closure glaucoma
title_short Changes of macular blood flow and structure in acute primary angle closure glaucoma
title_sort changes of macular blood flow and structure in acute primary angle closure glaucoma
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617959/
https://www.ncbi.nlm.nih.gov/pubmed/35781598
http://dx.doi.org/10.1007/s10792-022-02399-y
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