Triptolide-mediated downregulation of FLIP(S) in hepatoma cells occurs at the post-transcriptional level independently of proteasome-mediated pathways

Cellular c-FLIP prevents apoptosis mediated by death receptor through inhibiting activation of caspase-8. Therefore, when c-FLIP is downregulated or eliminated, caspase-8 activation is promoted, and death receptor ligand-induced apoptosis is activated. It was reported that triptolide (TPL) sensitize...

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Detalles Bibliográficos
Autores principales: Liu, Weixia, Yang, Ying, Wang, Jing, Wu, Shanshan, Chen, Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617966/
https://www.ncbi.nlm.nih.gov/pubmed/36308574
http://dx.doi.org/10.1007/s12032-022-01857-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617966/
https://www.ncbi.nlm.nih.gov/pubmed/36308574
http://dx.doi.org/10.1007/s12032-022-01857-y

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