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Triptolide-mediated downregulation of FLIP(S) in hepatoma cells occurs at the post-transcriptional level independently of proteasome-mediated pathways
Cellular c-FLIP prevents apoptosis mediated by death receptor through inhibiting activation of caspase-8. Therefore, when c-FLIP is downregulated or eliminated, caspase-8 activation is promoted, and death receptor ligand-induced apoptosis is activated. It was reported that triptolide (TPL) sensitize...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617966/ https://www.ncbi.nlm.nih.gov/pubmed/36308574 http://dx.doi.org/10.1007/s12032-022-01857-y |