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Natural scene sampling reveals reliable coarse-scale orientation tuning in human V1
Orientation selectivity in primate visual cortex is organized into cortical columns. Since cortical columns are at a finer spatial scale than the sampling resolution of standard BOLD fMRI measurements, analysis approaches have been proposed to peer past these spatial resolution limitations. It was r...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617970/ https://www.ncbi.nlm.nih.gov/pubmed/36309512 http://dx.doi.org/10.1038/s41467-022-34134-7 |
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author | Roth, Zvi N. Kay, Kendrick Merriam, Elisha P. |
author_facet | Roth, Zvi N. Kay, Kendrick Merriam, Elisha P. |
author_sort | Roth, Zvi N. |
collection | PubMed |
description | Orientation selectivity in primate visual cortex is organized into cortical columns. Since cortical columns are at a finer spatial scale than the sampling resolution of standard BOLD fMRI measurements, analysis approaches have been proposed to peer past these spatial resolution limitations. It was recently found that these methods are predominantly sensitive to stimulus vignetting - a form of selectivity arising from an interaction of the oriented stimulus with the aperture edge. Beyond vignetting, it is not clear whether orientation-selective neural responses are detectable in BOLD measurements. Here, we leverage a dataset of visual cortical responses measured using high-field 7T fMRI. Fitting these responses using image-computable models, we compensate for vignetting and nonetheless find reliable tuning for orientation. Results further reveal a coarse-scale map of orientation preference that may constitute the neural basis for known perceptual anisotropies. These findings settle a long-standing debate in human neuroscience, and provide insights into functional organization principles of visual cortex. |
format | Online Article Text |
id | pubmed-9617970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-96179702022-10-31 Natural scene sampling reveals reliable coarse-scale orientation tuning in human V1 Roth, Zvi N. Kay, Kendrick Merriam, Elisha P. Nat Commun Article Orientation selectivity in primate visual cortex is organized into cortical columns. Since cortical columns are at a finer spatial scale than the sampling resolution of standard BOLD fMRI measurements, analysis approaches have been proposed to peer past these spatial resolution limitations. It was recently found that these methods are predominantly sensitive to stimulus vignetting - a form of selectivity arising from an interaction of the oriented stimulus with the aperture edge. Beyond vignetting, it is not clear whether orientation-selective neural responses are detectable in BOLD measurements. Here, we leverage a dataset of visual cortical responses measured using high-field 7T fMRI. Fitting these responses using image-computable models, we compensate for vignetting and nonetheless find reliable tuning for orientation. Results further reveal a coarse-scale map of orientation preference that may constitute the neural basis for known perceptual anisotropies. These findings settle a long-standing debate in human neuroscience, and provide insights into functional organization principles of visual cortex. Nature Publishing Group UK 2022-10-29 /pmc/articles/PMC9617970/ /pubmed/36309512 http://dx.doi.org/10.1038/s41467-022-34134-7 Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Roth, Zvi N. Kay, Kendrick Merriam, Elisha P. Natural scene sampling reveals reliable coarse-scale orientation tuning in human V1 |
title | Natural scene sampling reveals reliable coarse-scale orientation tuning in human V1 |
title_full | Natural scene sampling reveals reliable coarse-scale orientation tuning in human V1 |
title_fullStr | Natural scene sampling reveals reliable coarse-scale orientation tuning in human V1 |
title_full_unstemmed | Natural scene sampling reveals reliable coarse-scale orientation tuning in human V1 |
title_short | Natural scene sampling reveals reliable coarse-scale orientation tuning in human V1 |
title_sort | natural scene sampling reveals reliable coarse-scale orientation tuning in human v1 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617970/ https://www.ncbi.nlm.nih.gov/pubmed/36309512 http://dx.doi.org/10.1038/s41467-022-34134-7 |
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