Opa1-mediated mitochondrial dynamics is important for osteoclast differentiation

Opatic atrophy 1 (Opa1) is a mitochondrial GTPase that regulates mitochondrial fusion and maintenance of cristae architecture. Osteoclasts are mitochondrial rich-cells. However, the role of Opa1 in osteoclasts remains unclear. Here, we demonstrate that Opa1- deficient osteoclast precursor cells do n...

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Detalles Bibliográficos
Autores principales: Nishikawa, Keizo, Takegami, Hina, Sesaki, Hiromi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618030/
https://www.ncbi.nlm.nih.gov/pubmed/36320616
http://dx.doi.org/10.17912/micropub.biology.000650
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author Nishikawa, Keizo
Takegami, Hina
Sesaki, Hiromi
author_facet Nishikawa, Keizo
Takegami, Hina
Sesaki, Hiromi
author_sort Nishikawa, Keizo
collection PubMed
description Opatic atrophy 1 (Opa1) is a mitochondrial GTPase that regulates mitochondrial fusion and maintenance of cristae architecture. Osteoclasts are mitochondrial rich-cells. However, the role of Opa1 in osteoclasts remains unclear. Here, we demonstrate that Opa1- deficient osteoclast precursor cells do not undergo efficient osteoclast differentiation and exhibit abnormal cristae morphology. Thus, Opa1 is a key factor in osteoclast differentiation through regulation of mitochondrial dynamics.
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spelling pubmed-96180302022-10-31 Opa1-mediated mitochondrial dynamics is important for osteoclast differentiation Nishikawa, Keizo Takegami, Hina Sesaki, Hiromi MicroPubl Biol New Finding Opatic atrophy 1 (Opa1) is a mitochondrial GTPase that regulates mitochondrial fusion and maintenance of cristae architecture. Osteoclasts are mitochondrial rich-cells. However, the role of Opa1 in osteoclasts remains unclear. Here, we demonstrate that Opa1- deficient osteoclast precursor cells do not undergo efficient osteoclast differentiation and exhibit abnormal cristae morphology. Thus, Opa1 is a key factor in osteoclast differentiation through regulation of mitochondrial dynamics. Caltech Library 2022-10-15 /pmc/articles/PMC9618030/ /pubmed/36320616 http://dx.doi.org/10.17912/micropub.biology.000650 Text en Copyright: © 2022 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Nishikawa, Keizo
Takegami, Hina
Sesaki, Hiromi
Opa1-mediated mitochondrial dynamics is important for osteoclast differentiation
title Opa1-mediated mitochondrial dynamics is important for osteoclast differentiation
title_full Opa1-mediated mitochondrial dynamics is important for osteoclast differentiation
title_fullStr Opa1-mediated mitochondrial dynamics is important for osteoclast differentiation
title_full_unstemmed Opa1-mediated mitochondrial dynamics is important for osteoclast differentiation
title_short Opa1-mediated mitochondrial dynamics is important for osteoclast differentiation
title_sort opa1-mediated mitochondrial dynamics is important for osteoclast differentiation
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618030/
https://www.ncbi.nlm.nih.gov/pubmed/36320616
http://dx.doi.org/10.17912/micropub.biology.000650
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AT takegamihina opa1mediatedmitochondrialdynamicsisimportantforosteoclastdifferentiation
AT sesakihiromi opa1mediatedmitochondrialdynamicsisimportantforosteoclastdifferentiation

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