FLASH X-ray spares intestinal crypts from pyroptosis initiated by cGAS-STING activation upon radioimmunotherapy

DNA-damaging treatments such as radiotherapy (RT) have become promising to improve the efficacy of immune checkpoint inhibitors by enhancing tumor immunogenicity. However, accompanying treatment-related detrimental events in normal tissues have posed a major obstacle to radioimmunotherapy and presen...

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Detalles Bibliográficos
Autores principales: Shi, Xiaolin, Yang, Yiwei, Zhang, Wei, Wang, Jianxin, Xiao, Dexin, Ren, Huangge, Wang, Tingting, Gao, Feng, Liu, Zhen, Zhou, Kui, Li, Peng, Zhou, Zheng, Zhang, Peng, Shen, Xuming, Liu, Yu, Zhao, Jianheng, Wang, Zhongmin, Liu, Fenju, Shao, Chunlin, Wu, Dai, Zhang, Haowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618056/
https://www.ncbi.nlm.nih.gov/pubmed/36256824
http://dx.doi.org/10.1073/pnas.2208506119

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