The intracellular Ca(2+) channel TRPML3 is a PI3P effector that regulates autophagosome biogenesis

Autophagy is a multiple fusion event, initiating with autophagosome formation and culminating with fusion with endo-lysosomes in a Ca(2+)-dependent manner. The source of Ca(2+) and the molecular mechanism by which Ca(2+) is provided for this process are not known. The intracellular Ca(2+) permeable...

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Detalles Bibliográficos
Autores principales: Kim, So Woon, Kim, Mi Kyung, Hong, Seokwoo, Choi, Areum, Choi, Jee Hye, Muallem, Shmuel, So, Insuk, Yang, Dongki, Kim, Hyun Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618060/
https://www.ncbi.nlm.nih.gov/pubmed/36252030
http://dx.doi.org/10.1073/pnas.2200085119

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