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Long noncoding RNA–mediated activation of PROTOR1/PRR5-AKT signaling shunt downstream of PI3K in triple-negative breast cancer

The phosphoinositide 3-kinase (PI3K) pathway represents the most hyperactivated oncogenic pathway in triple-negative breast cancer (TNBC), a highly aggressive tumor subtype encompassing ∼15% of breast cancers and which possesses no targeted therapeutics. Despite critical contributions of its signali...

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Detalles Bibliográficos
Autores principales:	Tu, Zhenbo, Hu, Yi, Raizada, Devesh, Bassal, Mahmoud A., Tenen, Daniel G., Karnoub, Antoine E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618063/ https://www.ncbi.nlm.nih.gov/pubmed/36269860 http://dx.doi.org/10.1073/pnas.2203180119

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