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Lysosomal positioning regulates Rab10 phosphorylation at LRRK2(+) lysosomes

Genetic variation at the leucine-rich repeat kinase 2 (LRRK2) locus contributes to an enhanced risk of familial and sporadic Parkinson’s disease. Previous data have demonstrated that recruitment to various membranes of the endolysosomal system results in LRRK2 activation. However, the mechanism(s) u...

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Detalles Bibliográficos
Autores principales:	Kluss, Jillian H., Beilina, Alexandra, Williamson, Chad D., Lewis, Patrick A., Cookson, Mark R., Bonet-Ponce, Luis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9618077/ https://www.ncbi.nlm.nih.gov/pubmed/36256825 http://dx.doi.org/10.1073/pnas.2205492119

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